Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Feb 20:16:609-618.
doi: 10.2147/IJGM.S400458. eCollection 2023.

Adverse Reactions of COVID-19 Vaccines: A Scoping Review of Observational Studies

Inge Dhamanti  1   2   3 , Auliya A Suwantika  4   5   6 , Amirah Adlia  7 , Laura Navika Yamani  8   9 , Fitri Yakub  10
Affiliations

Adverse Reactions of COVID-19 Vaccines: A Scoping Review of Observational Studies

Inge Dhamanti et al. Int J Gen Med. .

Abstract

The COVID-19 pandemic had a severe global impact. A range of campaigns and activities, including vaccines, are being implemented to counteract this pandemic. Using observational data, the goal of this scoping review is to identify adverse events connected with COVID-19 vaccinations. We conduct a scoping study and searched three databases from the start of the COVID-19 pandemic in 2020 through June 2022. Based on our criteria and searched keywords, the review included eleven papers in total, with the majority of the studies being conducted in developed countries. The study populations varied and included general community populations, healthcare professionals, military forces, and patients with systemic lupus and cancer. This study includes vaccines from Pfizer-BioNTech, Oxford-AstraZeneca, Sinopharm, and Moderna. The COVID-19 vaccine-related adverse events were classified into three types: local side effects, systemic side effects, and other side effects such as allergies. The adverse reactions to COVID-19 vaccines are mild to moderate in severity, with no significant influence or interference in individual daily activities and no unique patterns in cause of death among vaccine-related deaths. According to the findings of these investigations, the COVID-19 vaccine is safe to administer and induces protection. It is vital to convey accurate information to the public about vaccination side effects, potential adverse responses, and the safety level of the vaccines supplied. Multiple strategies must be implemented at the individual, organizational, and population levels to eliminate vaccine hesitance. Future studies could investigate the vaccine's effect on people of various ages and medical conditions.

Keywords: COVID-19 vaccines; adverse effect; vaccination impact; vaccine reactions.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest in this work.

References

    1. Wang J, Kaperak C, Sato T, Sakuraba A. COVID-19 reinfection: a rapid systematic review of case reports and case series. J Invest Med. 2021;69(6):1253–1255. doi: 10.1136/jim-2021-001853 - DOI - PubMed
    1. Rai P, Kumar BK, Deekshit VK, Karunasagar I, Karunasagar I. Detection technologies and recent developments in the diagnosis of COVID-19 infection. Appl Microbiol Biotechnol. 2021;105:441–455. doi: 10.1007/s00253-020-11061-5/Published - DOI - PMC - PubMed
    1. IHME. COVID-19 results briefing Myanmar current situation trends in drivers of transmission. COVID-19 Results Brief; 2022. Available from: https://www.healthdata.org/sites/default/files/covid_briefs/15_briefing_.... Accessed October 27, 2022.
    1. rawson T, Brewer T, Veltcheva D, Huntingford C, Bonsall MB. How and when to end the COVID-19 lockdown: an optimization approach. Front Public Health. 2020;8. doi: 10.3389/fpubh.2020.00262 - DOI - PMC - PubMed
    1. Shen M, Xiao Y, Zhuang G, Li Y, Zhang L. Mass testing—An underexplored strategy for COVID-19 control. Innovation. 2021;2(2):100114. doi: 10.1016/j.xinn.2021.100114 - DOI - PMC - PubMed

Publication types