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. 2020 Dec 14;2(1):iqaa006.
doi: 10.1093/oxfimm/iqaa006. eCollection 2021.

Medawar and the immunological paradox of pregnancy: in context

Victoria Male  1
Affiliations

Medawar and the immunological paradox of pregnancy: in context

Victoria Male. Oxf Open Immunol. .

Abstract

In 1953, Peter Medawar defined 'the immunological paradox of pregnancy', whereby the semi-allogeneic foetus can survive for 9 months in its mother, while a semi-allogeneic graft would be rejected. Here, I revisit the immunological paradox of pregnancy, setting it in the context of the time in which it was proposed. I go on to examine the extent to which Medawar's ideas on the subject have stood the test of time and how they have shaped reproductive immunology.

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