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Review
. 2023 Feb 10:15:1122300.
doi: 10.3389/fnagi.2023.1122300. eCollection 2023.

Clinical antidiabetic medication used in Alzheimer's disease: From basic discovery to therapeutics development

Juan Huang  1   2   3 , Nanqu Huang  4 , Di Cui  2 , Jingshan Shi  2 , Yu Qiu  1
Affiliations
Review

Clinical antidiabetic medication used in Alzheimer's disease: From basic discovery to therapeutics development

Juan Huang et al. Front Aging Neurosci. .

Abstract

Alzheimer's disease (AD) is a common neurodegenerative disease. Type 2 diabetes mellitus (T2DM) appears to increase and contributing to the risk of AD. Therefore, there is increasing concern about clinical antidiabetic medication used in AD. Most of them show some potential in basic research, but not in clinical research. So we reviewed the opportunities and challenges faced by some antidiabetic medication used in AD from basic to clinical research. Based on existing research progress, this is still the hope of some patients with special types of AD caused by rising blood glucose or/and insulin resistance.

Keywords: Alzheimer’s disease; antidiabetic medication; clinical research; type 2 diabetes mellitus; type 3 diabetes mellitus (T3DM).

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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