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Review
. 2023 Feb 23;7(1):011501.
doi: 10.1063/5.0137026. eCollection 2023 Mar.

Nanosized drug delivery strategies in osteosarcoma chemotherapy

Chenglong Chen, Shidong Wang  1 , Juan Wang  2 , Fangzhou Yao  3 , Xiaodong Tang  1 , Wei Guo  1
Affiliations
Review

Nanosized drug delivery strategies in osteosarcoma chemotherapy

Chenglong Chen et al. APL Bioeng. .

Abstract

Despite recent developments worldwide in the therapeutic care of osteosarcoma (OS), the ongoing challenges in overcoming limitations and side effects of chemotherapy drugs warrant new strategies to improve overall patient survival. Spurred by rapid progress in biomedicine, nanobiotechnology, and materials chemistry, chemotherapeutic drug delivery in treatment of OS has become possible in recent years. Here, we review recent advances in the design of drug delivery system, especially for chemotherapeutic drugs in OS, and discuss the relative merits in trials along with future therapeutic options. These advances may pave the way for novel therapies requisite for patients with OS.

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Figures

FIG. 1.
FIG. 1.
Co-occurrence analysis of global research in PubMed about OS and drug delivery. The size of the points represents the frequency of keywords. (a) Mapping of keywords in OS and delivery system of chemotherapeutic drugs. (b) Mapping of keywords in OS and delivery system of all antineoplastic reagents.
FIG. 2.
FIG. 2.
Different physical and chemical stimuli exploited for triggering smart nanoparticles in controlled drug release, namely, pH shift, ultrasound agitation, light irradiation, magnetic induction, redox reaction, enzyme activation, and temperature change. Adapted with permission from Karimi et al., Chem. Soc. Rev. 45(5), 1457 (2016). Copyright 2016 Copyright Clearance Center, Inc.
FIG. 3.
FIG. 3.
BM-MSC derived exosomes loaded with doxorubicin. The evaluation of the antitumor effect of this system both in vitro (a) and in vivo (b). Adapted with permission from Wei et al., Int. J. Nanomed. 17, 35959282 (2022). Copyright 2022 Authors, licensed under a Creative Commons Attribution (CC BY) license.
FIG. 4.
FIG. 4.
pH-responsive and self-degradable DNA nano-capsule for doxorubicin delivery. (a) pH-triggered self-degradable DNA nano-capsule for doxorubicin release. (b) Schematic illustration of efficient delivery of doxorubicin to nuclei for cancer therapy (I) internalization in endosomes; (II) pH-triggered degradation of the DNA nanoclew for drug release; and (III) accumulation of doxorubicin in cell nuclei. Adapted with permission from Jiang et al., J. Am. Chem. Soc. 136(42), 14722–14725 (2014). Copyright 2014 Authors, licensed under a Creative Commons Attribution (CC BY) license.
FIG. 5.
FIG. 5.
RBC membrane-derived vesicles combined microfluidic technology for in vivo tumor MRI and photothermal therapy. (a) Structure characterization of RBC-magnetic nanoparticles. (b) Performance characterization of RBC-magnetic nanoparticles. (c) In vitro characterization of the immune escape and photothermal capabilities of RBC-magnetic nanoparticles. (d) In vivo tumor MRI and therapy of RBC-magnetic nanoparticles. (e) In vivo tumor photothermal therapy with RBC-magnetic nanoparticles. Adapted with permission from Zhou et al., Mater. Sci. Eng.: C 114, 111006 (2020). Copyright 2020 Elsevier.
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