Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Feb 13;25(3):142.
doi: 10.3892/etm.2023.11841. eCollection 2023 Mar.

Nutritional and prognostic value of bioelectrical phase angle as a potentially modifiable marker in acute myeloid leukemia

Tiantian Jiang  1 , Yue Weng  1 , Nan Zhang  2 , Xiaoqiong Tang  1
Affiliations

Nutritional and prognostic value of bioelectrical phase angle as a potentially modifiable marker in acute myeloid leukemia

Tiantian Jiang et al. Exp Ther Med. .

Abstract

Phase angle (PhA), as measured by bioelectrical impedance analysis, is an important parameter in nutritional assessment and is highly predictive of clinical outcomes in various diseases; however, there is little research on its use in acute myeloid leukemia (AML). Therefore, the present study was conducted to determine the association between PhA and malnutrition and to clarify the prognostic significance of PhA for progression-free survival (PFS) and overall survival (OS) in adult patients with AML (excluding acute promyelocytic leukemia) who were undergoing chemotherapy. A total of 70 patients with newly diagnosed AML were enrolled. After chemotherapy, the nutritional risk for patients with a reduced baseline PhA increased significantly. Disease progression occurred in 28 patients, of which 23 died, with a median follow-up of 9.3 months. A reduced baseline PhA was associated with poor PFS (7.1 months vs. 11.6 months; P=0.001) and OS (8.2 months vs. 12.1 months; P=0.011). A multivariate analysis revealed that a reduced PhA was an independent risk factor for disease progression (hazard ratio, 3.13; 95% CI, 1.21-8.11; P=0.019). Overall, these results suggested that PhA is an effective and sensitive indicator that may provide important nutritional and prognostic information in patients with AML.

Keywords: acute myeloid leukemia; bioelectrical impedance analysis; chemotherapy; nutrition; phase angle; survival.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Flow chart of the study design and patient selection criteria. AML, acute myeloid leukemia; APL, acute promyelocytic leukemia; BIA, bioelectrical impedance analysis; HSCT, hematopoietic stem-cell transplantation.
Figure 2
Figure 2
Kaplan-Meier curves for (A) PFS and (B) OS. PFS, progression-free survival; OS, overall survival; PhA, phase angle; HR, hazard ratio; CI, confidence interval.
See this image and copyright information in PMC

References

    1. Krug U, Röllig C, Koschmieder A, Heinecke A, Sauerland MC, Schaich M, Thiede C, Kramer M, Braess J, Spiekermann K, et al. Complete remission and early death after intensive chemotherapy in patients aged 60 years or older with acute myeloid leukaemia: A web-based application for prediction of outcomes. Lancet. 2010;376:2000–2008. doi: 10.1016/S0140-6736(10)62105-8. - DOI - PubMed
    1. Döhner H, Estey EH, Amadori S, Appelbaum FR, Büchner T, Burnett AK, Dombret H, Fenaux P, Grimwade D, Larson RA, et al. Diagnosis and management of acute myeloid leukemia in adults: Recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood. 2010;115:453–474. doi: 10.1182/blood-2009-07-235358. - DOI - PubMed
    1. De Kouchkovsky I, Abdul-Hay M. ‘Acute myeloid leukemia: A comprehensive review and 2016 update’. Blood Cancer J. 2016;6(e441) doi: 10.1038/bcj.2016.50. - DOI - PMC - PubMed
    1. Le Blanc K, Ringdén O, Remberger M. A low body mass index is correlated with poor survival after allogeneic stem cell transplantation. Haematologica. 2003;88:1044–1052. - PubMed
    1. Bay JO, Dendoncker C, Angeli M, Biot T, Chikhi M, Combal C, Jouannic L, Kermeur G, Lopvet L, Marchand T, et al. Nutritional management for patients hospitalized during allogeneic stem cell transplantation: Guidelines from the Francophone society of bone marrow transplantation and cellular therapy (SFGM-TC) Bull Cancer. 2016;103 (11S):S201–S206. doi: 10.1016/j.bulcan.2016.09.014. (In French) - DOI - PubMed