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. 2023 Feb 8:16:1117121.
doi: 10.3389/fnmol.2023.1117121. eCollection 2023.

Commentary: Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors

Jihu Zhao  1   2 , Peng Sun  2 , Heng Liu  1
Affiliations

Commentary: Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors

Jihu Zhao et al. Front Mol Neurosci. .
No abstract available

Keywords: anxiety disorders; anxiolytic; basolateral amygdala; midbrain; ventral tegmental area.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Graphical summary of the VTA connections with other brain regions and the main functions regarding each different projection. Forms and positions can only represent the general structure and position. The lines with arrows only represent a simplified schematic of the general projection pattern. VTA stands for Ventral Tegmental Area; LHA stands for lateral hypothalamic area; BLA stands for basolateral amygdala; Vp stands for ventral pallidum; NAc stands for Nucleus Accumbens; BNST stands for bed nucleus of the stria terminalis; mPFC stands for medial prefrontal Cortex; LHb stands for lateral habenula; HP stands for Hippocampus; vlPAG stands for ventrolateral periaqueductal gray; LDTg stands for laterodorsal tegmentum; LC stands for locus coeruleus.
Figure 2
Figure 2
VTA-BLA neuronal activity controls anxiety-like behavior. Inhibition of VTA-BLA neuronal activity could produce anxiety-like behavior; activation of VTA-BLA neuronal activity could produce anxiolytic effects.
See this image and copyright information in PMC

References

    1. Alvarsson A., Caudal D., Björklund A., Svenningsson P. (2016). Emotional memory impairments induced by AAV-mediated overexpression of human α-synuclein in dopaminergic neurons of the ventral tegmental area. Behav. Brain Res. 296, 129–133. 10.1016/j.bbr.08034 - DOI - PubMed
    1. Balon R., Starcevic V. (2020). Role of benzodiazepines in anxiety disorders. Adv. Exp. Med. Biol. 1191, 20. 10.1007./978-981-32-9705-0_20 - DOI - PubMed
    1. Behlke L. M., Lenze E. J., Carney R. M. (2020). The cardiovascular effects of newer antidepressants in older adults and those with or at high risk for cardiovascular diseases. CNS Drugs 34, 1133–1147. 10.1007./s40263-020-00763-z - DOI - PMC - PubMed
    1. Chaudhury D., Walsh J. J., Friedman A. K., Juarez B., Kuet S. M. (2013). Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature 493, 7433. 10.1038./nature11713 - DOI - PMC - PubMed
    1. Choi K. W., Kim Y. K., Jeon H. J. (2020). Comorbid anxiety and depression: clinical and conceptual consideration and transdiagnostic treatment. Adv. Exp. Med. Biol. 1191, 219–235. 10.1007./978-981-32-9705-0_14 - DOI - PubMed

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