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. 2023 Feb 22;11(2):23259671231151925.
doi: 10.1177/23259671231151925. eCollection 2023 Feb.

Relationship Between Activity Level and Knee Function Is Influenced by Negative Affect in Patients Undergoing Cell Therapy for Articular Cartilage Defects in the Knee

Timothy Hopkins  1   1 , Sally Roberts  1   2 , James Bruce Richardson  1 , Pete Gallacher  2 , Andrea Bailey  2 , Jan Herman Kuiper  1   2
Affiliations

Relationship Between Activity Level and Knee Function Is Influenced by Negative Affect in Patients Undergoing Cell Therapy for Articular Cartilage Defects in the Knee

Timothy Hopkins et al. Orthop J Sports Med. .

Abstract

Background: Increased activity level is generally reported to be positively related to improved knee function after knee surgery. However, little research has been conducted into this relationship on an individual patient basis, or the influence of demographic and psychosocial factors such as patient affect-the subjective experience of emotion.

Hypothesis: The relationship between postoperative activity level and knee function will vary between patients and will be influenced by the patients' affect and demographic characteristics.

Study design: Cohort study; Level of evidence, 3.

Methods: Activity, knee function, demographic, and affect data were collected from patients enrolled in an ongoing trial for the treatment of articular cartilage lesions at preoperative and 2-, 12-, and 15-month postoperative points. Quantile mixed regression modeling was used to determine the patient-to-patient variation in activity level and knee function. Multiple linear regression and partial correlation analyses were performed to determine whether demographic characteristics and patient affect were associated with this variation.

Results: A total of 62 patients were included in the study (23 female; 39 male; mean age, 38.3 ± 9.5 years). We found substantial variation between patients in the relationship between activity level and knee function, with most patients (n = 56) demonstrating a positive relation (positive slope), but 6 patients demonstrating a negative relation (negative slope). A negative affect (NA) score was significantly correlated with the slope between activity level and knee function (r S = -0.30; P = .018) and was a significant individual predictor of knee function at 15 months postoperatively (coefficient = -3.5; P = .025).

Conclusion: Our results suggest that the relationship between activity level and knee function varies between patients. The patients with a higher NA score were likely to report smaller improvements in knee function with increasing activity levels compared with those with a lower NA score.

Keywords: cartilage repair; cell therapy; knee function; physical activity; psychosocial factors.

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Conflict of interest statement

One or more of the authors has declared the following potential conflict of interest or source of funding: This study was funded by the Orthopaedic Institute Ltd (grant No. RPG143), Versus Arthritis (grant No. 18480, 19429, and 21156), and the Medical Research Council (grant No. MR/L010453/1 and MR/N02706X/1). AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto.

Figures

Figure 1.
Figure 1.
Plots of the individual patient plots resulting from a quantile mixed model with random intercept and slope of the data set, excluding the 2-month follow-up. The plots represent the individual relationship between activity level and knee function (Lysholm score) at the 3 time points assessed (baseline, 12 months, and 15 months). The median (fixed effects) slope between the AAS and Lysholm scores was positive (0.97 [95% CI, 0.79-1.14]; P < .001). The majority (n = 56) of patients demonstrated a positive slope, but 6 patients (patients 11, 20, 30, 44, 47, and 61) demonstrated a negative slope. AAS, adjusted activity score.
Figure 2.
Figure 2.
A scatter plot to demonstrate the correlation between individual patient slopes and mean NA scores, with the 2-month follow-up data excluded. The slope was used as a measure with which to summarize the relationship between activity level and knee function at baseline and 12-month and 15-month follow-ups. Slopes created from these 3 time points were significantly correlated with the mean NA (r S = –0.30 [95% CI, –0.51 to –0.05]; P = .018). PANAS, Positive and Negative Affect Schedule–Short Form. NA, negative affect.
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