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Comment
. 2023 Mar 21;205(3):e0001323.
doi: 10.1128/jb.00013-23. Epub 2023 Feb 27.

Complex Signaling Networks Control Coxiella burnetii

David R Thomas  1 , Hayley J Newton  1
Affiliations
Comment

Complex Signaling Networks Control Coxiella burnetii

David R Thomas et al. J Bacteriol. .

Abstract

A recent study by S. Wachter, C. L. Larson, K. Virtaneva, K. Kanakabandi, et al. (J Bacteriol 205:e00416-22, 2023, https://doi.org/10.1128/JB.00416-22) utilizes new technologies to examine the role of two-component systems in Coxiella burnetii. This research demonstrates that the zoonotic pathogen C. burnetii mediates complex transcriptional control, throughout different bacterial phases and environmental conditions, with relatively few regulatory elements.

Keywords: CRISPRi; Coxiella burnetii; environmental response; signalling; two-component system.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

FIG 1
FIG 1
Double KDs of C. burnetii orphan RRs reveal a complicated network. Lines connect RR pairs, solid green lines indicate no effect on intracellular replication, and dashed red lines indicate that the double KD significantly reduces replication in Vero cells.
See this image and copyright information in PMC

Comment on

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