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. 2023 Feb;77(1):29-36.
doi: 10.18926/AMO/64358.

Increased Glycine-conjugated and Unconjugated Bile Acid Levels Associated with Aggravation of Nonalcoholic Steatohepatitis and Cardiovascular Disease in SHRSP5/Dmcr Rat

Shusei Yamamoto  1   2 , Ikumi Sato  2 , Moe Fujii  2 , Mai Kakimoto  2 , Koki Honma  2 , Natsumi Akiyama  3 , Miku Sakai  3 , Natsuki Fukuhama  3 , Shota Kumazaki  2 , Satoshi Hirohata  1 , Kazuya Kitamori  4 , Yukio Yamori  5 , Shogo Watanabe  1
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Free article

Increased Glycine-conjugated and Unconjugated Bile Acid Levels Associated with Aggravation of Nonalcoholic Steatohepatitis and Cardiovascular Disease in SHRSP5/Dmcr Rat

Shusei Yamamoto et al. Acta Med Okayama. 2023 Feb.
Free article

Abstract

The SHRSP5/Dmcr is a useful animal model for the development of nonalcoholic steatohepatitis (NASH) pathology when fed a high-fat, high-cholesterol diet, and further drug interventions can lead to concomitant cardiovascular disease. While SHRSP5/Dmcr rats have been used for basic research related to NASH, details of their bile acid metabolism in this condition are unknown. In this study, we aimed to clarify the changes in the serum bile acid (BA) fractions associated with NASH and found that glycine-conjugated and unconjugated bile acid increased with worsening NASH and cardiovascular disease while taurine-conjugated BA relatively decreased.

Keywords: SHRSP5/Dmc; cardiovascular disease; glycine-conjugated bile acids; nonalcoholic steatohepatitis; unconjugated bile acids.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

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