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. 2023 May 24;188(6):800-816.
doi: 10.1093/bjd/ljad043.

Clinical features in adults with acquired cutis laxa: a retrospective review

Katie A O'Connell  1   2 , Morgan Schaefer  1 , Lihi Atzmony  3   4   5 , Ruth Ann Vleugels  1 , Keith Choate  3 , Avery H LaChance  1 , Michelle S Min  1   6
Affiliations

Clinical features in adults with acquired cutis laxa: a retrospective review

Katie A O'Connell et al. Br J Dermatol. .

Abstract

Acquired cutis laxa (ACL) is a very rare dermatological condition with numerous proposed aetiologies. Herein, we report on 10 adult patients with ACL, three of which were found to have genetic mutations suggesting a genetic predisposition for the development of ACL following exposure to an environmental insult. Four patients were presumed to develop ACL in association with medication exposure. Overall, if a case of potential ACL arises, providers should carefully review patient history and comorbidities, perform thorough systemic investigations based on symptomatology, and consider genetic analysis.

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Conflict of interest statement

Conflicts of interest A.H.L. is the PI for a research grant from Pfizer exploring the role of the JAK/STAT pathway in connective tissue disease. M.S.M. is on the advisory board of Horizon.

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