Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Feb 8:21:1523-1532.
doi: 10.1016/j.csbj.2023.02.006. eCollection 2023.

Mathematical modeling of regulatory networks of intracellular processes - Aims and selected methods

Malgorzata Kardynska  1 , Daria Kogut  1   2 , Marcin Pacholczyk  1   2 , Jaroslaw Smieja  1   2
Affiliations
Review

Mathematical modeling of regulatory networks of intracellular processes - Aims and selected methods

Malgorzata Kardynska et al. Comput Struct Biotechnol J. .

Abstract

Regulatory networks structure and signaling pathways dynamics are uncovered in time- and resource consuming experimental work. However, it is increasingly supported by modeling, analytical and computational techniques as well as discrete mathematics and artificial intelligence applied to to extract knowledge from existing databases. This review is focused on mathematical modeling used to analyze dynamics and robustness of these networks. This paper presents a review of selected modeling methods that facilitate advances in molecular biology.

Keywords: Modeling; Regulatory networks; Signaling pathways.

PubMed Disclaimer

Figures

ga1
Graphical abstract
Fig. 1
Fig. 1
Intertwining biological and modeling research to expand knowledge in molecular biology and in biomedicine in general.
Fig. 2
Fig. 2
Actual time response of a signaling pathway (grey dashed line) and misleading results of experiments with several time-point measurements (black crosses).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Airley R. John Wiley & Sons: Hoboken; NJ, USA: 2009. (Cancer Chemotherapy: Basic Science to the Clinic). ISBN: 978–1-118–96384-5.
    1. Amin D.N., Campbell M.R., Moasser M.M. The role of HER3, the unpretentious member of the HER family, in cancer biology and cancer therapeutics. Semin Cell Dev Biol. 2010;21:944–950. doi: 10.1016/j.semcdb.2010.08.007. - DOI - PMC - PubMed
    1. Arata Y., Takagi H. Quantitative studies for cell-division cycle control. Front Physiol. 2019;10:1022. doi: 10.3389/fphys.2019.01022. - DOI - PMC - PubMed
    1. R.P. Araujo, S.T. Vittadello and M.P.H. Stumpf, "Bayesian and Algebraic Strategies to Design in Synthetic Biology, in Proceedings of the IEEE, vol. 110, no. 5, pp. 675–687, May 2022, doi: 10.1109/JPROC.2021.3129527.
    1. Baaske J., Gonschorek P., Engesser R., Dominguez-Monedero A., Raute K., Fischbach P., Müller K., Cachat E., Schamel W.W.A., Minguet S., Davies J.A., Timmer J., Weber W., Zurbriggen M.D. Dual-controlled optogenetic system for the rapid down-regulation of protein levels in mammalian cells. Sci Rep. 2018;8(1):15024. doi: 10.1038/s41598-018-32929-7. - DOI - PMC - PubMed

LinkOut - more resources