Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Feb 21:16:479-498.
doi: 10.2147/CCID.S401206. eCollection 2023.

Global Trends and Research Progress of Photodynamic Therapy in Skin Cancer: A Bibliometric Analysis and Literature Review

Jiachen Sun #  1 , Hongqing Zhao #  1 , Lin Fu #  2 , Jing Cui #  3 , Yuguang Yang  1
Affiliations
Review

Global Trends and Research Progress of Photodynamic Therapy in Skin Cancer: A Bibliometric Analysis and Literature Review

Jiachen Sun et al. Clin Cosmet Investig Dermatol. .

Abstract

Background: Based on photochemical reactions through the combined use of light and photosensitizers, photodynamic therapy (PDT) is gaining popularity for the treatment of skin cancer. Various photosensitizers and treatment regimens are continuously being developed for enhancing the efficacy of PDT on skin cancer. Reviewing the development history of PDT on skin cancer, and summarizing its development direction and research status, is conducive to the further research.

Methods: To evaluate the research trends and map knowledge structure, all publications covering PDT on skin cancer were retrieved and extracted from Web of Science database. We applied VOSviewer and CiteSpace softwares to evaluate and visualize the countries, institutes, authors, keywords and research trends. Literature review was performed for the analysis of the research status of PDT on skin cancer.

Results: A total of 2662 publications were identified. The elements, mechanism, pros and cons, representative molecular photosensitizers, current challenges and research progress of PDT on skin cancer were reviewed and summarized.

Conclusion: This study provides a comprehensive display of the field of PDT on skin cancer, which will help researchers further explore the mechanism and application of PDT more effectively and intuitively.

Keywords: bibliometric; photodynamic therapy; photosensitizers; skin cancer.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Flow diagram of literature selection and screening in this study.
Figure 2
Figure 2
Overall distribution of publication outputs of PDT on skin cancer. (A) Global annual output trends of PDT on skin cancer. (B) The growth trends of publications related to PDT on skin cancer of the top five countries.
Figure 3
Figure 3
The contributions and cooperation of countries/regions in the field of PDT on skin cancer. Circles with larger diameters represent countries with more publications.
Figure 4
Figure 4
The contributions and cooperation of different institutions focusing on PDT on skin cancer. Circles with larger diameters represent institutions with more publications.
Figure 5
Figure 5
Visual cluster analysis of top authors in the field of PDT on skin cancer. Circles with larger diameters represent authors with more publications.
Figure 6
Figure 6
Journal analysis in the field of PDT on skin cancer. Circles with larger diameters represent journals with more publications.
Figure 7
Figure 7
Timeline distribution of the top 20 keywords in the field of PDT on skin cancer.
See this image and copyright information in PMC

References

    1. Qu Z, Wang Z, Qiu S, Cui G, Li C. Efficacy of photodynamic therapy with 5-aminolevulinic acid for the treatment of cervical high-grade squamous intraepithelial lesions with high-risk HPV infection: a retrospective study. Photodiagnosis Photodyn Ther. 2022;40:103068. doi: 10.1016/j.pdpdt.2022.103068 - DOI - PubMed
    1. Pham TC, Nguyen VN, Choi Y, Lee S, Yoon J. Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy. Chem Rev. 2021;121:13454–13619. doi: 10.1021/acs.chemrev.1c00381 - DOI - PubMed
    1. Tang D, Yu Y, Zhang J, et al. Self-sacrificially degradable pseudo-semiconducting polymer nanoparticles that integrate NIR-II fluorescence bioimaging, photodynamic immunotherapy, and photo-activated chemotherapy. Adv Mater. 2022;34(34):e2203820. doi: 10.1002/adma.202203820 - DOI - PubMed
    1. Stockwell BR. Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications. Cell. 2022;185:2401–2421. doi: 10.1016/j.cell.2022.06.003 - DOI - PMC - PubMed
    1. Zhang S, Sun X, Wang Z, et al. Molecularly self-engineered nanoamplifier for boosting photodynamic therapy via cascade oxygen elevation and Lipid ROS accumulation. ACS Appl Mater Interfaces. 2022;14(34):38497–38505. doi: 10.1021/acsami.2c09209 - DOI - PubMed