Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 May;50(5):3184-3190.
doi: 10.1002/mp.16333. Epub 2023 Mar 10.

Technical note: Measurement of the bunch structure of a clinical proton beam using a SiPM coupled to a plastic scintillator with an optical fiber

Affiliations

Technical note: Measurement of the bunch structure of a clinical proton beam using a SiPM coupled to a plastic scintillator with an optical fiber

Miguel García Díez et al. Med Phys. 2023 May.

Abstract

Background: Recent proposals of high dose rate plans in protontherapy as well as very short proton bunches may pose problems to current beam monitor systems. There is an increasing demand for real-time proton beam monitoring with high temporal resolution, extended dynamic range and radiation hardness. Plastic scintillators coupled to optical fiber sensors have great potential in this context to become a practical solution towards clinical implementation.

Purpose: In this work, we evaluate the capabilities of a very compact fast plastic scintillator with an optical fiber readout by a SiPM and electronics sensor which has been used to provide information on the time structure at the nanosecond level of a clinical proton beam.

Materials and methods: A 3 × 3 × 3 mm3 plastic scintillator (EJ-232Q Eljen Technology) coupled to a 3 × 3 mm2 SiPM (MicroFJ-SMA-30035, Onsemi) has been characterized with a 70 MeV clinical proton beam accelerated in a Proteus One synchrocyclotron. The signal was read out by a high sampling rate oscilloscope (5 GS/s). By exposing the sensor directly to the proton beam, the time beam profile of individual spots was recorded.

Results: Measurements of detector signal have been obtained with a time sampling period of 0.8 ns. Proton bunch period (16 ns), spot (10 μs) and interspot (1 ms) time structures could be observed in the time profile of the detector signal amplitude. From this, the RF frequency of the accelerator has been extracted, which is found to be 64 MHz.

Conclusions: The proposed system was able to measure the fine time structure of a clinical proton accelerator online and with ns time resolution.

Keywords: FLASH-RT; RF frequency; fine time structure measurement; plastic scintillator fiber optic detector; time resolution.

PubMed Disclaimer

References

REFERENCES

    1. Favaudon V, Caplier L, Monceau V, et al. Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice. Sci Transl Med. 2014;6(245):245ra293. https://doi.org/10.1126/scitranslmed.3008973
    1. Friedl AA, Prise KM, Butterworth KT, Montay-Gruel P, Favaudon V. Radiobiology of the FLASH effect. In: Medical Physics. Vol 49, John Wiley and Sons Ltd; 2022:1993-2013. https://doi.org/10.1002/mp.15184
    1. Labarbe R, Hotoiu L, Barbier J, Favaudon V. A physicochemical model of reaction kinetics supports peroxyl radical recombination as the main determinant of the FLASH effect. Radiother Oncol. 2020;153:303-310. https://doi.org/10.1016/j.radonc.2020.06.001
    1. Jansen J, Beyreuther E, García-Calderón D, et al. Changes in Radical Levels as a Cause for the FLASH effect: impact of beam structure parameters at ultra-high dose rates on oxygen depletion in water. Radiother Oncol. 2022;175:193-196. Published online August 2022:S0167814022042451. https://doi.org/10.1016/j.radonc.2022.08.024
    1. Espinosa-Rodriguez A, Sanchez-Parcerisa D, Ibáñez P, et al. Radical production with pulsed beams: understanding the transition to FLASH. Int J Mol Sci. 2022;23(21):13484. https://doi.org/10.3390/ijms232113484

LinkOut - more resources