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. 2023 Mar 16;67(3):e0113022.
doi: 10.1128/aac.01130-22. Epub 2023 Feb 28.

Hospital Clonal Outbreak of Fluconazole-Resistant Candida parapsilosis Harboring the Y132F ERG11p Substitution in a French Intensive Care Unit

Simona Presente  1 , Christine Bonnal  2 , Anne-Cécile Normand  3 , Yannick Gaudonnet  4 , Arnaud Fekkar  3 , Jean-François Timsit  1   5 , Solen Kernéis  4   5
Affiliations

Hospital Clonal Outbreak of Fluconazole-Resistant Candida parapsilosis Harboring the Y132F ERG11p Substitution in a French Intensive Care Unit

Simona Presente et al. Antimicrob Agents Chemother. .

Abstract

We report the first identification of a fluconazole-resistant Candida parapsilosis (FR-Cp) strain in our hospital, which subsequently caused an outbreak involving 17 patients (12 deaths) within a 26-bed French intensive care unit. Microsatellite genotyping confirmed that all FR-Cp isolates belonged to the same clone. Given recent reports of rapid dissemination of these emerging clones, routine testing of azole susceptibility for all Candida parapsilosis isolates should be encouraged, at least in ICU patients.

Keywords: Candida parapsilosis; fluconazole resistance; infection prevention and control; intensive care unit; outbreak.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

FIG 1
FIG 1
Chronogram of cases of fluconazole-resistant C. parapsilosis (FR-Cp) infections or colonizations over the study period. Gray bars represent the dates of stay in the ICU. Vertical lines figure the date of detection of the FR-Cp: black, superficial swab samples (axilla, groin, anus, mouth); red, blood, urine, central venous catheter tip. †, patients who died during ICU stay.
See this image and copyright information in PMC

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