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. 2023 May;27(5):837-849.
doi: 10.1007/s10995-023-03591-x. Epub 2023 Feb 28.

Prevalence, Pattern, and Outcome of Congenital Anomalies Admitted to a Neonatal Unit in a Low-Income Country-a Ten-Year Retrospective Study

Betty Anane-Fenin  1   2 , Douglas Aninng Opoku  3 , Lawrence Chauke  4   5
Affiliations

Prevalence, Pattern, and Outcome of Congenital Anomalies Admitted to a Neonatal Unit in a Low-Income Country-a Ten-Year Retrospective Study

Betty Anane-Fenin et al. Matern Child Health J. 2023 May.

Abstract

Objective: The incidence of congenital abnormalities is highest in low-and-middle-income countries. However, the prevalence, spectrum, trends of neonatal congenital anomalies and their admission outcomes have not been well explored. This study was a 10 year retrospective hospital-based research in a low-income country to address the above.

Methods: All infants hospitalized in the Special Care Baby Unit at the Cape Coast Teaching Hospital in Ghana, between 1st January 2010 and 31st December 2019, had their demographic, obstetric, and clinical data recorded.

Results: Over the decade, 236 neonates with congenital abnormalities were admitted to the unit, accounting for 2.8% of total neonatal admissions and 8.6 per 1000 births. Mortality occurred in 33.2% of neonates with congenital abnormalities, corresponding to 4.6% of all neonatal deaths. Mortality was significantly associated with place of delivery and gravidity of more than five. The commonest anomalies were in the nervous system, particularly neural tube defects, followed by suspected chromosomal abnormalities and then cardiac defects. Neonates with cardiac defects had a higher chance of dying. Health center/clinic delivery proffered a better survival than hospital delivery, but this should be interpreted with caution.

Conclusion: Neural tube defects were the most predominant anomalies; hence, intensification of preconception and antenatal folic acid supplementation is pivotal towards their reduction. Making prenatal screening for early detection of fetal anomalies an integral part of routine antenatal care is also essential. This research was conducted in a single center and did not include stillbirths and abortions so cannot give an accurate estimation of the number of congenital abnormalities in the population. A national registry of congenital anomalies is recommended.

Keywords: Admission outcome; Birth defects; Congenital abnormalities; Congenital anomalies; Neonates.

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Conflict of interest statement

No conflicts of interest to declare.

Figures

Fig. 1
Fig. 1
Birthweight of neonates
Fig. 2
Fig. 2
Gestational age and admission outcomes
Fig. 3
Fig. 3
Kaplan–Meier survival estimates for gravidity and place of delivery
See this image and copyright information in PMC

References

    1. Abbey M, Oloyede OA, Bassey G, Kejeh BM, Otaigbe BE, Opara PI, Eneh AU, Akani CI. Prevalence and pattern of birth defects in a tertiary health facility in the Niger Delta area of Nigeria. International Journal of Women’s Health. 2017;9:115–121. doi: 10.2147/IJWH.S108905. - DOI - PMC - PubMed
    1. Adane F, Afework M, Seyoum G, Gebrie A. Prevalence and associated factors of birth defects among newborns in sub-saharan african countries: A systematic review and meta-analysis. Pan African Medical Journal. 2020;36:1–22. doi: 10.11604/pamj.2020.36.19.19411. - DOI - PMC - PubMed
    1. Agha MM, Williams JI, Marrett L, To T, Dodds L. Determinants of survival in children with congenital abnormalities: A long-term population-based cohort study. Birth Defects Research Part A—Clinical and Molecular Teratology. 2006;76(1):46–54. doi: 10.1002/bdra.20218. - DOI - PubMed
    1. Agot GN, Mweu MM, Wang’ombe JK. Prevalence of major external structural birth defects in Kiambu County, Kenya 2014–2018. PAMJ. 2020;37(187):1–13. doi: 10.11604/PAMJ.2020.37.187.26289. - DOI - PMC - PubMed
    1. Ajao AE, Adeoye IA. Prevalence, risk factors and outcome of congenital anomalies among neonatal admissions in OGBOMOSO. Nigeria. BMC Pediatrics. 2019;19(1):1–10. doi: 10.1186/S12887-019-1471-1/TABLES/4. - DOI - PMC - PubMed