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. 2023 Jun 1;42(6):443-448.
doi: 10.1097/INF.0000000000003884. Epub 2023 Feb 21.

Comparing the Etiology of Viral Acute Respiratory Illnesses Between Children Who Do and Do Not Attend Childcare

Peter M DeJonge  1 , Arnold S Monto  1 , Ryan E Malosh  1 , Joshua G Petrie  2 , Amy Callear  1 , Hannah E Segaloff  3 , Rachel Truscon  1 , Emileigh Johnson  1 , Bonnie Cheng  1 , Mara Cranis  1 , Katie Tiseo  1 , Sydney Foote  1 , Adrienne Musci  4 , Emily T Martin  1
Affiliations

Comparing the Etiology of Viral Acute Respiratory Illnesses Between Children Who Do and Do Not Attend Childcare

Peter M DeJonge et al. Pediatr Infect Dis J. .

Abstract

Background and objective: Childcare attendance is a common risk factor for acute respiratory illness (ARI) in young children. Our goal was to better understand the specific respiratory viruses that predominate in childcare, which may support the development of tailored illness prevention and intervention strategies in childcare settings.

Methods: Using data from a prospective household cohort of ARI surveillance, we assessed specimen from 1418 ARIs reported by 359 childcare-aged children over 6 study seasons (2012/2013 through 2017/2018). Respiratory swabs were tested by polymerase chain reaction for 9 respiratory viruses. A mixed-effect logistic regression model was used to compare odds of various viral detection outcomes. The Shannon's Diversity index was used to compare the richness (ie, number of species) and diversity (ie, relative species abundance) associated with respiratory viruses detected in both groups.

Results: At least 1 virus was detected in 75.5% of childcare-associated ARIs and in 80.1% of homecare ARIs. Compared with illnesses among homecare children, childcare illnesses were associated with significantly higher odds of detected adenovirus (odds ratio = 1.86, 95% confidence interval = 1.05-3.28) and human metapneumovirus (odds ratio = 1.76, 95% confidence interval = 1.03-3.0). The pool of viruses associated with childcare ARI was found to be significantly richer and more diverse than that of viruses associated with homecare ARI ( P < 0.0001).

Conclusions: Children attending childcare experience a higher risk of adenovirus and human metapneumovirus infection and are regularly exposed to a rich and diverse pool of respiratory viruses in childcare environments. Our results underscore the necessity of thorough and multifaceted viral prevention strategies in childcare settings.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

References

    1. Simoes EAF, Cherian T, Chow J, Shahid-Salles SA, Laxminarayan R, John TJ. Acute Respiratory Infections in Children. nd, Jamison DT, Breman JG, Measham AR, Alleyne G, Claeson M, , editors. In: Disease Control Priorities in Developing Countries; 2006.
    1. Fleming DW, Cochi SL, Hightower AW, et al. Childhood upper respiratory tract infections: to what degree is incidence affected by day-care attendance? Pediatrics. 1987;79:55–60.
    1. Hurwitz ES, Gunn WJ, Pinsky PF, et al. Risk of respiratory illness associated with day-care attendance: a nationwide study. Pediatrics. 1991;87:62–69.
    1. Ball TM, Holberg CJ, Aldous MB, et al. Influence of attendance at day care on the common cold from birth through 13 years of age. Arch Pediatr Adolesc Med. 2002;156:121–126.
    1. Sun Y, Sundell J. Early daycare attendance increase the risk for respiratory infections and asthma of children. J Asthma. 2011;48:790–796.

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