Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2023 Apr;11(2):e01068.
doi: 10.1002/prp2.1068.

Evaluation of the effects of isoproterenol on arrhythmia recurrence following catheter ablation in patients with atrioventricular nodal re-entrant tachycardia: A randomized controlled clinical trial

Neda Vahid Lotfabadi  1 , Saeed Mehrabi  1 , Alireza Heidari-Bakavoli  1 , Negar Morovatdar  2 , Mohammad Tayyebi  1 , Vafa Baradaran Rahimi  1   3
Affiliations
Randomized Controlled Trial

Evaluation of the effects of isoproterenol on arrhythmia recurrence following catheter ablation in patients with atrioventricular nodal re-entrant tachycardia: A randomized controlled clinical trial

Neda Vahid Lotfabadi et al. Pharmacol Res Perspect. 2023 Apr.

Abstract

We aimed to determine the effects of isoproterenol on arrhythmia recurrence in atrioventricular nodal re-entrant tachycardia (AVNRT) patients treated with catheter ablation. The present randomized controlled clinical trial was conducted on AVNRT patients candidates for radiofrequency ablation (RFA). The patients were randomly assigned to receive isoproterenol (0.5-4 μg/min) or not (control group) for arrhythmia re-induction after ablation. The results of the electrophysiological (EP) study, the ablation parameters, and the arrhythmia recurrence rate were recorded. We evaluated 206 patients (53 males and 153 females) with a mean (SD) age of 49.87 (15.5) years in two groups of isoproterenol (n = 103) and control (n = 103). No statistically significant difference was observed between the two studied groups in age, gender, EP study, and ablation parameters. The success rate of ablation was 100% in both groups. During ~16.5 months of follow-up, one patient (1%) in the isoproterenol group and four patients (3.8%) in the control group experienced AVNRT recurrence (HR = 0.245; 95% confidence interval [CI], 0.043-1.418; p = .173). Based on the Kaplan-Meier analysis, there was no significant difference in the incidence rate of arrhythmia recurrence during the follow-up period between the two studied groups (p = .129). Additionally, there were no significant differences between the arrhythmia's recurrence according to age, gender, junctional rhythm, type of AVNRT arrhythmia, and DAVN persistence after ablation. Although isoproterenol administration for arrhythmia re-induction after ablation did not alleviate the treatment outcomes and arrhythmia recurrence following RFA in AVNRT patients, further studies with a larger sample size and a longer duration of follow-up are necessary.

Keywords: arrhythmia recurrence; atrioventricular nodal reentry; catheter ablation; isoproterenol.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there is no conflict of interest.

Figures

FIGURE 1
FIGURE 1
The flowchart of the study.
FIGURE 2
FIGURE 2
Kaplan‐Mayer curve showing arrhythmia recurrence in AVNRT patients in isoproterenol and control groups.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Katritsis DG, Camm AJ. Atrioventricular nodal reentrant tachycardia. Circulation. 2010;122(8):831‐840. - PubMed
    1. Shafiee‐Nick R, Afshari AR, Mousavi SH, et al. A comprehensive review on the potential therapeutic benefits of phosphodiesterase inhibitors on cardiovascular diseases. Biomed Pharmacother. 2017;94:541‐556. - PubMed
    1. Katritsis DG. Catheter ablation of atrioventricular nodal re‐entrant tachycardia: facts and fiction. Arrhythm Electrophysiol Rev. 2018;7(4):230‐231. - PMC - PubMed
    1. Sugumar H, Tung M, Leather R, Lane C, Sterns LD, Novak PG. Atrioventricular nodal non Re‐entrant tachycardia (AVNNT). Heart Lung Circ. 2017;26(5):524‐525. - PubMed
    1. Sohinki D, Obel OA. Current trends in supraventricular tachycardia management. Ochsner J. 2014;14(4):586‐595. - PMC - PubMed

Publication types

LinkOut - more resources