Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 May-Jun;73(3):233-254.
doi: 10.3322/caac.21772. Epub 2023 Mar 1.

Colorectal cancer statistics, 2023

Rebecca L Siegel  1 , Nikita Sandeep Wagle  1 , Andrea Cercek  2 , Robert A Smith  3 , Ahmedin Jemal  1
Affiliations
Free article

Colorectal cancer statistics, 2023

Rebecca L Siegel et al. CA Cancer J Clin. 2023 May-Jun.
Free article

Abstract

Colorectal cancer (CRC) is the second most common cause of cancer death in the United States. Every 3 years, the American Cancer Society provides an update of CRC statistics based on incidence from population-based cancer registries and mortality from the National Center for Health Statistics. In 2023, approximately 153,020 individuals will be diagnosed with CRC and 52,550 will die from the disease, including 19,550 cases and 3750 deaths in individuals younger than 50 years. The decline in CRC incidence slowed from 3%-4% annually during the 2000s to 1% annually during 2011-2019, driven partly by an increase in individuals younger than 55 years of 1%-2% annually since the mid-1990s. Consequently, the proportion of cases among those younger than 55 years increased from 11% in 1995 to 20% in 2019. Incidence since circa 2010 increased in those younger than 65 years for regional-stage disease by about 2%-3% annually and for distant-stage disease by 0.5%-3% annually, reversing the overall shift to earlier stage diagnosis that occurred during 1995 through 2005. For example, 60% of all new cases were advanced in 2019 versus 52% in the mid-2000s and 57% in 1995, before widespread screening. There is also a shift to left-sided tumors, with the proportion of rectal cancer increasing from 27% in 1995 to 31% in 2019. CRC mortality declined by 2% annually from 2011-2020 overall but increased by 0.5%-3% annually in individuals younger than 50 years and in Native Americans younger than 65 years. In summary, despite continued overall declines, CRC is rapidly shifting to diagnosis at a younger age, at a more advanced stage, and in the left colon/rectum. Progress against CRC could be accelerated by uncovering the etiology of rising incidence in generations born since 1950 and increasing access to high-quality screening and treatment among all populations, especially Native Americans.

Keywords: colon and rectum neoplasms; early-onset colorectal cancer; epidemiology; health disparities; screening and early detection.

PubMed Disclaimer

References

REFERENCES

    1. Islami F, Goding Sauer A, Miller KD, et al. Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States. CA Cancer J Clin. 2018;68(1):31-54. doi:10.3322/caac.21440
    1. Winawer SJ, Zauber AG. The advanced adenoma as the primary target of screening. Gastrointest Endosc Clin N Am. 2002;12(1):1-9, v. doi:10.1016/s1052-5157(03)00053-9
    1. Surveillance, Epidemiology, and End Results (SEER) Program. SEER*Stat Database: North American Association of Central Cancer Registries (NAACCR) Incidence Data-Cancer in North America Research Data, 1995-2019, with Race/Ethnicity, Standard File, American Cancer Society Facts & Figures Projection Project (which includes data from the Centers for Disease Control and Prevention’s National Program of Cancer Registries, the Canadian Counsel of Cancer Registry’s Provincial and Territorial Registries, and the National Cancer Institute’s SEER Registries), certified by the NAACCR as meeting high-quality data standards for the specified time periods, submitted December 2021, Surveillance Systems Branch, Surveillance Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute; 2022.
    1. Clegg LX, Feuer EJ, Midthune DN, Fay MP, Hankey BF. Impact of reporting delay and reporting error on cancer incidence rates and trends. J Natl Cancer Inst. 2002;94(20):1537-1545. doi:10.1093/jnci/94.20.1537
    1. Surveillance, Epidemiology, and End Results (SEER) Program. SEER*Stat Database: Incidence-SEER Research Data with Delay Adjustment, 8 Registries, Malignant Only (1975-2019)-Linked to County Attributes-time dependent (1990-2019) income/rurality, 1969-2020 counties, submitted November 2021. Surveillance Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute; 2022.