Financial disclosures/conflicts of interest: This project received funding from the University of California San Francisco (UCSF) Inquiry Funding Office and was supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through UCSF-CTSI Grant Number UL1 TR001872. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. This project was also made possible in part by unrestricted grant funding from That Man May See (San Francisco, CA) and Research to Prevent Blindness (New York, NY) to the University of California San Francisco, Department of Ophthalmology.