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. 2023 Jun:116:11-15.
doi: 10.1016/j.clinbiochem.2023.02.011. Epub 2023 Feb 27.

High serum levels of galectins 1 and 4 in osteoarthritis patients

Priscilla Stela Santana de Oliveira  1 , Pablo Ramon Gualberto Cardoso  1 , Simão Kalebe de Paula Silva  1 , Angela Luzia Branco Pinto Duarte  2 , Michelle Melgarejo da Rosa  1 , Moacyr Jesus Barreto de Melo Rêgo  3 , Michelly Cristiny Pereira  1 , Ivan da Rocha Pitta  1 , Maira Galdino da Rocha Pitta  1
Affiliations

High serum levels of galectins 1 and 4 in osteoarthritis patients

Priscilla Stela Santana de Oliveira et al. Clin Biochem. 2023 Jun.

Abstract

Background: Although immunostaining of galectins is associated with cartilage damage, the serum levels of these lectins in osteoarthritis (OA) are not fully understood.

Objective: Therefore, we evaluate the concentrations of galectins-1, 3, 4, and 7 in patients with osteoarthritis and correlate them with clinical parameters.

Methods: This cross-sectional study involved 60 osteoarthritis patients and 43 healthy volunteers, who had serum samples collected for galectins titration by Enzyme-Linked Immunosorbent Assay (ELISA).

Results: Our finds showed that the median values of gal-1 and 4 serum levels in patients were statistically higher (13,990 and 969.1 pg/mL, respectively) than in healthy controls (1,798 and 519.5 pg/mL) with p < 0.001. Further, gal-1 expressed higher levels in patients who had joint edema at the time of collection with a median value of 14,970 pg/mL.

Conclusion: Surprisingly, galectin-4 appears to be involved in the osteoarthritis inflammation process as the well-known galectin-1.

Keywords: Cartilage; ECM; Glycans; Joint.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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