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Editorial
. 2023 Mar 2;141(9):969-970.
doi: 10.1182/blood.2022019019.

A novel RIPK1 inhibitor attenuates GVHD

Geoffrey R Hill  1   2 , Motoko Koyama  1
Affiliations
Editorial

A novel RIPK1 inhibitor attenuates GVHD

Geoffrey R Hill et al. Blood. .
No abstract available

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Conflict of interest statement

Conflict-of-interest disclosure: G.R.H. has consulted for Generon Corporation, NapaJen Pharma, iTeos Therapeutics, Neoleukin Therapeutics and has received research funding from Compass Therapeutics, Syndax Pharmaceuticals, Applied Molecular Transport, Serplus Technology, Heat Biologics, Laevoroc Oncology, Genentech, and iTeos Therapeutics. M.K. declares no competing financial interests.

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References

    1. Yu X, Ma H, Li B, et al. A novel RIPK1 inhibitor reduces GVHD in mice via a nonimmunosuppressive mechanism that restores intestinal homeostasis. Blood. 2023;141(9):1070–1086. - PubMed
    1. Zeiser R, Blazar BR. Acute graft-versus-host disease - biologic process, prevention, and therapy. N Engl J Med. 2017;377(22):2167–2179. - PMC - PubMed
    1. Koyama M, Hill GR. The primacy of gastrointestinal tract antigen-presenting cells in lethal graft-versus-host disease. Blood. 2019;134(24):2139–2148. - PMC - PubMed
    1. Patankar JV, Becker C. Cell death in the gut epithelium and implications for chronic inflammation. Nat Rev Gastroenterol Hepatol. 2020;17(9):543–556. - PubMed
    1. Matsuzawa-Ishimoto Y, Hine A, Shono Y, et al. An intestinal organoid-based platform that recreates susceptibility to T-cell-mediated tissue injury. Blood. 2020;135(26):2388–2401. - PMC - PubMed

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