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. 2023 Mar 2;18(3):e0282004.
doi: 10.1371/journal.pone.0282004. eCollection 2023.

Pentraxin 3 in the cerebrospinal fluid during central nervous system infections: A retrospective cohort study

Martin Munthe Thomsen  1 , Lea Munthe-Fog  2 , Pelle Trier Petersen  1 , Thore Hillig  3 , Lennart Jan Friis-Hansen  4 , Casper Roed  1 , Zitta Barrella Harboe  1   5 , Christian Thomas Brandt  1   5   6
Affiliations

Pentraxin 3 in the cerebrospinal fluid during central nervous system infections: A retrospective cohort study

Martin Munthe Thomsen et al. PLoS One. .

Erratum in

Abstract

The present study describes diagnostic and prognostic abilities of Cerebrospinal fluid (CSF) Pentraxin 3 (PTX3) in central nervous system (CNS) infections. CSF PTX3 was measured retrospectively from 174 patients admitted under suspicion of CNS infection. Medians, ROC curves and Youdens index was calculated. CSF PTX3 was significantly higher among all CNS infections and undetectable in most of the patients in the control group, and significantly higher in bacterial infections compared to viral and Lyme infections. No association was found between CSF PTX3 and Glasgow Outcome Score. PTX3 in the CSF can distinguish bacterial infection from viral and Lyme infections and non-CNS infections. Highest levels were found in bacterial meningitis. No prognostic abilities were found.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Scatter dot plot of PTX3 concentration in the CSF.
Error bars indicate IQR.
Fig 2
Fig 2. ROC curves for PTX3 diagnostic abilities.
A) Bacterial meningitis versus Viral meningitis and Viral encephalitis. B) Viral meningitis versus Control group. C) Viral encephalitis versus Control group. D) Lyme disease versus Control group.
Fig 3
Fig 3. PTX3 correlation to CSF cell count, CSF polynuclear cell count and CSF protein concentration.
See this image and copyright information in PMC

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