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. 2023 Jun 1;50(6):e8-e10.
doi: 10.1097/OLQ.0000000000001793. Epub 2023 Mar 2.

Healthy Vaccinee Bias and MenB-FHbp Vaccine Effectiveness Against Gonorrhea

Winston E Abara  1 , Kyle T Bernstein  1 , Felicia M T Lewis, Preeti Pathela  2 , Aras Islam  3 , Michael Eberhart  3 , Iris Cheng  4 , Alexandra Ternier  4 , Jennifer Sanderson Slutsker  2 , Robbie Madera  3 , Robert Kirkcaldy  1
Affiliations

Healthy Vaccinee Bias and MenB-FHbp Vaccine Effectiveness Against Gonorrhea

Winston E Abara et al. Sex Transm Dis. .

Abstract

Observational studies demonstrated 30% to 40% effectiveness of outer-membrane vesicle (OMV) meningococcal serogroup B vaccines against gonorrhea. To explore whether healthy vaccinee bias influenced such findings, we examined the effectiveness of MenB-FHbp, a non-OMV vaccine that is not protective against gonorrhea. MenB-FHbp was ineffective against gonorrhea. Healthy vaccinee bias likely did not confound earlier studies of OMV vaccines.

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Conflict of interest statement

Conflict of Interest and Sources of Funding: None declared.

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