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Case Reports
. 1987 Dec;102(6):941-8.

Lethal hyperparathyroid crisis: hazards of phosphate administration

A M Vernava 3rd  1 , L W O'Neal, V Palermo
Affiliations
  • PMID: 3686357
Case Reports

Lethal hyperparathyroid crisis: hazards of phosphate administration

A M Vernava 3rd et al. Surgery. 1987 Dec.

Abstract

Two patients with hypercalcemia crisis and parathyroid adenoma died as a result of pulmonary insufficiency. The administration of phosphate is believed to have contributed to the deaths, since the pulmonary problems appeared when the blood [Ca] X [PO4] product rose and extensive metastatic calcification was present in the pulmonary alveolar lining. The use of phosphates as calcium-lowering agents in hypercalcemia is discouraged, because phosphate appears to lower calcium levels only by intravascular precipitation.

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