Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jun 1;93(11):e53-e55.
doi: 10.1016/j.biopsych.2023.01.014. Epub 2023 Mar 1.

Dual-Target Deep Brain Stimulation for Obsessive-Compulsive Disorder and Tourette Syndrome

Affiliations

Dual-Target Deep Brain Stimulation for Obsessive-Compulsive Disorder and Tourette Syndrome

Ricardo A Najera et al. Biol Psychiatry. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Patient 1 (left), patient 2 (right). (A) Multi-Modality Visualization Tool reconstructions of patient brains showing frontal and superior views of cortical surfaces, labeled subcortical structures, and deep brain stimulation (DBS) leads. (B) Clinical scores over time (days since lead implantation). Vertical lines (black) indicate when stimulation was turned on at each anatomic target; lines are initially dotted for patient 2 to indicate lack of data during that time, and color-coded dotted lines for each clinical scale indicate threshold for response to treatment. (C) Timeline indicating patient programming visits and use of event markers (by anatomic target) and surveys completed over time; four example power spectral densities (PSDs) are shown for select event markers and surveys for each patient. ERP, exposure and response prevention; GPi, globus pallidus internus; HAMD, Hamilton Depression Rating Scale; VC, ventral capsule; VS, ventral striatum; YBOCS, Yale-Brown Obsessive Compulsive Scale; YGTSS, Yale Global Tic Severity Scale.

References

    1. Gadot R, Najera R, Hirani S, Anand A, Storch E, Goodman WK, et al. (2022): Efficacy of deep brain stimulation for treatment-resistant obsessive-compulsive disorder: Systematic review and metaanalysis [published online ahead of print Sep 20]. J Neurol Neurosurg Psychiatry. - PubMed
    1. Martinez-Ramirez D, Jimenez-Shahed J, Leckman JF, Porta M, Servello D, Meng FG, et al. (2018): Efficacy and safety of deep brain stimulation in Tourette syndrome: The International Tourette Syndrome Deep Brain Stimulation Public Database and Registry. JAMA Neurol 75:353–359. - PMC - PubMed
    1. Billnitzer A, Jankovic J (2020): Current management of tics and Tourette syndrome: Behavioral, pharmacologic, and surgical treatments. Neurotherapeutics 17:1681–1693. - PMC - PubMed
    1. Arya S, Filkowski MM, Nanda P, Sheth SA (2019): Deep brain stimulation for obsessive-compulsive disorder. Bull Menninger Clin 83:84–96. - PubMed
    1. Baldermann JC, Hennen C, Schüller T, Andrade P, Visser-Vandewalle V, Horn A, et al. (2022): Normative functional connectivity of thalamic stimulation for reducing tic severity in Tourette syndrome. Biol Psychiatry Cogn Neurosci Neuroimaging 7:841–844. - PubMed

Publication types