Viral pathogens increase risk of neurodegenerative disease

doi:10.1038/s41582-023-00790-6

Comment

. 2023 May;19(5):259-260.

doi: 10.1038/s41582-023-00790-6.

Viral pathogens increase risk of neurodegenerative disease

Britanie M Blackhurst¹, Kristen E Funk²

Affiliations

¹ Department of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC, USA.
² Department of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC, USA. kfunk@uncc.edu.

PMID: 36864169
PMCID: PMC9980857
DOI: 10.1038/s41582-023-00790-6

Comment

Viral pathogens increase risk of neurodegenerative disease

Britanie M Blackhurst et al. Nat Rev Neurol. 2023 May.

. 2023 May;19(5):259-260.

doi: 10.1038/s41582-023-00790-6.

Authors

Britanie M Blackhurst¹, Kristen E Funk²

Affiliations

¹ Department of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC, USA.
² Department of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC, USA. kfunk@uncc.edu.

PMID: 36864169
PMCID: PMC9980857
DOI: 10.1038/s41582-023-00790-6

Erratum in

Author Correction: Viral pathogens increase risk of neurodegenerative disease.
Blackhurst BM, Funk KE. Blackhurst BM, et al. Nat Rev Neurol. 2024 Mar;20(3):197. doi: 10.1038/s41582-024-00931-5. Nat Rev Neurol. 2024. PMID: 38243009 No abstract available.

Abstract

A new study, drawing on data from national biobanks, adds to the growing evidence that exposure to common viral pathogens increases the risk of Alzheimer disease and other neurodegenerative diseases. These findings might provide insights into the initiating factors that lead to neurodegeneration.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Comment on

Virus exposure and neurodegenerative disease risk across national biobanks.
Levine KS, Leonard HL, Blauwendraat C, Iwaki H, Johnson N, Bandres-Ciga S, Ferrucci L, Faghri F, Singleton AB, Nalls MA. Levine KS, et al. Neuron. 2023 Apr 5;111(7):1086-1093.e2. doi: 10.1016/j.neuron.2022.12.029. Epub 2023 Jan 19. Neuron. 2023. PMID: 36669485 Free PMC article.

Cited by

ACH2.0/E, the Consolidated Theory of Conventional and Unconventional Alzheimer's Disease: Origins, Progression, and Therapeutic Strategies.
Volloch V, Rits-Volloch S. Volloch V, et al. Int J Mol Sci. 2024 May 30;25(11):6036. doi: 10.3390/ijms25116036. Int J Mol Sci. 2024. PMID: 38892224 Free PMC article. Review.
Neurotropic virus infection and neurodegenerative diseases: Potential roles of autophagy pathway.
Zhao YJ, Xu KF, Shu FX, Zhang F. Zhao YJ, et al. CNS Neurosci Ther. 2024 Jun;30(6):e14548. doi: 10.1111/cns.14548. Epub 2023 Dec 11. CNS Neurosci Ther. 2024. PMID: 38082503 Free PMC article. Review.
miRNAs: Targets to Investigate Herpesvirus Infection Associated with Neurological Disorders.
de Souza Carneiro VC, Leon LAA, de Paula VS. de Souza Carneiro VC, et al. Int J Mol Sci. 2023 Nov 1;24(21):15876. doi: 10.3390/ijms242115876. Int J Mol Sci. 2023. PMID: 37958855 Free PMC article. Review.
Arbovirus infection increases the risk for the development of neurodegenerative disease pathology in the murine model.
Fongsaran C, Jirakanwisal K, Peng BH, Fracassi A, Taglialatela G, Dineley KT, Paessler S, Cisneros IE. Fongsaran C, et al. Brain Behav Immun Health. 2024 Apr 24;38:100780. doi: 10.1016/j.bbih.2024.100780. eCollection 2024 Jul. Brain Behav Immun Health. 2024. PMID: 38706571 Free PMC article.
Animal models of post-acute COVID-19 syndrome: a call for longitudinal animal studies.
Dai J, He F, Chen Q, Li Q, Zhao L, Du Y. Dai J, et al. Front Immunol. 2025 Feb 26;16:1521029. doi: 10.3389/fimmu.2025.1521029. eCollection 2025. Front Immunol. 2025. PMID: 40079013 Free PMC article. Review.

See all "Cited by" articles

References

1. Lotz SK, Blackhurst BM, Reagin KL, Funk KE. Microbial infections are a risk factor for neurodegenerative diseases. Front. Cell. Neurosci. 2021;15:691136. doi: 10.3389/fncel.2021.691136. - DOI - PMC - PubMed
1. Griciuc A, Tanzi RE. The role of innate immune genes in Alzheimer’s disease. Curr. Opin. Neurol. 2021;34:228–236. doi: 10.1097/WCO.0000000000000911. - DOI - PMC - PubMed
1. Parhizkar S, Holtzman DM. APOE mediated neuroinflammation and neurodegeneration in Alzheimer’s disease. Semin. Immunol. 2022;59:101594. doi: 10.1016/j.smim.2022.101594. - DOI - PMC - PubMed
1. Levine KS, et al. Virus exposure and neurodegenerative disease risk across national biobanks. Neuron. 2023 doi: 10.1016/j.neuron.2022.12.029. - DOI - PMC - PubMed
1. Bjornevik K, et al. Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis. Science. 2022;375:296–301. doi: 10.1126/science.abj8222. - DOI - PubMed

Publication types

Actions

MeSH terms

Actions
Actions

LinkOut - more resources

Full Text Sources
Medical
- MedlinePlus Health Information

[1] Lotz SK, Blackhurst BM, Reagin KL, Funk KE. Microbial infections are a risk factor for neurodegenerative diseases. Front. Cell. Neurosci. 2021;15:691136. doi: 10.3389/fncel.2021.691136. - DOI - PMC - PubMed

[2] Lotz SK, Blackhurst BM, Reagin KL, Funk KE. Microbial infections are a risk factor for neurodegenerative diseases. Front. Cell. Neurosci. 2021;15:691136. doi: 10.3389/fncel.2021.691136. - DOI - PMC - PubMed

[3] Griciuc A, Tanzi RE. The role of innate immune genes in Alzheimer’s disease. Curr. Opin. Neurol. 2021;34:228–236. doi: 10.1097/WCO.0000000000000911. - DOI - PMC - PubMed

[4] Griciuc A, Tanzi RE. The role of innate immune genes in Alzheimer’s disease. Curr. Opin. Neurol. 2021;34:228–236. doi: 10.1097/WCO.0000000000000911. - DOI - PMC - PubMed

[5] Parhizkar S, Holtzman DM. APOE mediated neuroinflammation and neurodegeneration in Alzheimer’s disease. Semin. Immunol. 2022;59:101594. doi: 10.1016/j.smim.2022.101594. - DOI - PMC - PubMed

[6] Parhizkar S, Holtzman DM. APOE mediated neuroinflammation and neurodegeneration in Alzheimer’s disease. Semin. Immunol. 2022;59:101594. doi: 10.1016/j.smim.2022.101594. - DOI - PMC - PubMed

[7] Levine KS, et al. Virus exposure and neurodegenerative disease risk across national biobanks. Neuron. 2023 doi: 10.1016/j.neuron.2022.12.029. - DOI - PMC - PubMed

[8] Levine KS, et al. Virus exposure and neurodegenerative disease risk across national biobanks. Neuron. 2023 doi: 10.1016/j.neuron.2022.12.029. - DOI - PMC - PubMed

[9] Bjornevik K, et al. Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis. Science. 2022;375:296–301. doi: 10.1126/science.abj8222. - DOI - PubMed

[10] Bjornevik K, et al. Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis. Science. 2022;375:296–301. doi: 10.1126/science.abj8222. - DOI - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Viral pathogens increase risk of neurodegenerative disease

Affiliations

Viral pathogens increase risk of neurodegenerative disease

Authors

Affiliations

Erratum in

Abstract

Conflict of interest statement

Comment on

Similar articles

Cited by

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical

Erratum in

Abstract

Conflict of interest statement

Comment on

Similar articles

Cited by

References

Publication types

MeSH terms

Related information

LinkOut - more resources

Full Text Sources

Medical