Isavuconazole as an alternative for antifungal prophylaxis in patients with hematological malignancies: Is the signal sufficient to support clinical practice?

Armelle Perez-Cortes Villalobos^{1

2}, Eric J Bow^{1

2

3

4

5}

Affiliations

¹ Department of Medical Microbiology and Infectious Diseases, Max Rady School of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
² Section of Infectious Diseases, Department of Internal Medicine, Max Rady School of Medicine, The University of Manitoba, Winnipeg, Manitoba, Canada.
³ Section of Haematology/Oncology, Department of Internal Medicine, Max Rady School of Medicine, The University of Manitoba, Winnipeg, Manitoba, Canada.
⁴ Department of Medical Oncology and Haematology, CancerCare Manitoba, Winnipeg, Manitoba, Canada.
⁵ Infection Control Services, CancerCare Manitoba, Winnipeg, Manitoba, Canada.

Editorial

Armelle Perez-Cortes Villalobos et al. Transpl Infect Dis. 2023 Apr.

. 2023 Apr;25(2):e14046.

doi: 10.1111/tid.14046. Epub 2023 Mar 2.

Armelle Perez-Cortes Villalobos^{1

2}, Eric J Bow^{1

2

3

4

5}

¹ Department of Medical Microbiology and Infectious Diseases, Max Rady School of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
² Section of Infectious Diseases, Department of Internal Medicine, Max Rady School of Medicine, The University of Manitoba, Winnipeg, Manitoba, Canada.
³ Section of Haematology/Oncology, Department of Internal Medicine, Max Rady School of Medicine, The University of Manitoba, Winnipeg, Manitoba, Canada.
⁴ Department of Medical Oncology and Haematology, CancerCare Manitoba, Winnipeg, Manitoba, Canada.
⁵ Infection Control Services, CancerCare Manitoba, Winnipeg, Manitoba, Canada.

No abstract available

References

1. Zeng H, Wu Z, Yu B, et al. Network meta-analysis of triazole, polyene, and echinocandin antifungal agents in invasive fungal infection prophylaxis in patients with hematological malignancies. BMC Cancer. 2021;21(1):404. https://doi.org/10.1186/s12885-021-07973-8
1. Bow EJ, Laverdiere M, Lussier N, Rotstein C, Cheang MS, Ioannou S. Antifungal prophylaxis for severely neutropenic chemotherapy recipients: a meta analysis of randomized-controlled clinical trials. Cancer. 2002;94(12):3230-3246.
1. Taplitz RA, Kennedy EB, Bow EJ, et al. Antimicrobial prophylaxis for adult patients with cancer-related immunosuppression: ASCO and IDSA clinical practice guideline update. J Clin Oncol. 2018;36(30):3043-3054. https://doi.org/10.1200/JCO.18.00374
1. Bow EJ, Vanness DJ, Slavin M, et al. Systematic review and mixed treatment comparison meta-analysis of randomized clinical trials of primary oral antifungal prophylaxis in allogeneic hematopoietic cell transplant recipients. BMC Infect Dis. 2015;15:128. https://doi.org/10.1186/s12879-015-0855-6
1. Lewis JS, 2nd, Wiederhold NP, Hakki M, Thompson GR, 3rd. New perspectives on antimicrobial agents: isavuconazole. Antimicrob Agents Chemother. 2022;66(9):e0017722. https://doi.org/10.1128/aac.00177-22