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Review
. 2023 Feb 14:14:1070779.
doi: 10.3389/fimmu.2023.1070779. eCollection 2023.

Immune checkpoint molecules in prevention and development of asthma

Zahra Kanannejad  1 , Saeede Soleimanian  1 , Zahra Ghahramani  2 , Najmeh Sepahi  1 , Milad Mohkam  1 , Soheila Alyasin  1 , Nasim Kheshtchin  1   3
Affiliations
Review

Immune checkpoint molecules in prevention and development of asthma

Zahra Kanannejad et al. Front Immunol. .

Abstract

Allergic asthma is a respiratory disease initiated by type-2 immune responses characterized by secretion of alarmins, interleukin-4 (IL-4), IL-5, and IL-13, eosinophilic inflammation, and airway hyperresponsiveness (AHR). Immune checkpoints (ICPs) are inhibitory or stimulatory molecules expressed on different immune cells, tumor cells, or other cell types that regulate immune system activation and maintain immune homeostasis. Compelling evidence indicates a key role for ICPs in both the progression and prevention of asthma. There is also evidence of asthma development or exacerbation in some cancer patients receiving ICP therapy. The aim of this review is to provide an updated overview of ICPs and their roles in asthma pathogenesis, and to assess their implications as therapeutic targets in asthma.

Keywords: asthma; autoimmunity; co-inhibitory signals; co-stimulatory signals; immune checkpoint.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Immune checkpoints in the development and prevention of asthma. The development of asthma is associated with increased Th2 response results in secretion of IL-4, 5, 13, and IgE production. Inhibitory and stimulatory immune checkpoint molecules expressing on different immune cells as well as on lung epithelium, contribute to development (left) or prevention (right) of allergic inflammatory responses through interaction with their ligands on different cell types including APCs. Th2: T helper 2; IL: interleukin.
See this image and copyright information in PMC

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