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. 2023 Feb 14:10:1097287.
doi: 10.3389/fsurg.2023.1097287. eCollection 2023.

Clinical characteristics of primary atrial tumor and their diagnostic value: A retrospective study of 10 years

Qian Wang  1 , Yue Jiang  1 , Li Lin  1 , Sheng Li  1 , Jiagao Lv  1 , Jun Chen  2
Affiliations

Clinical characteristics of primary atrial tumor and their diagnostic value: A retrospective study of 10 years

Qian Wang et al. Front Surg. .

Abstract

Background: Primary atrial tumors are relatively rare and predominantly benign. However, some atrial tumors may be malignant and are associated with poor outcome. Currently, it is hard to determine the malignance of atrial tumors by preoperative clinical presentation or by echocardiography. We aimed to report the difference in the clinical characteristics of patients with benign and malignant atrial tumor.

Methods: This was a single-center retrospective study. A total of 194 patients with primary atrial tumor admitted to our center between 2012 and 2021 were included. The clinical characteristics of patients with benign and malignant tumor were compared.

Results: Benign and malignant tumor accounted for 93% (n = 180) and 7% (n = 14) of the total patients, respectively. Malignant atrial tumor tended to occur in younger patients (P < 0.05), was more likely to be located at the right atrium (P < 0.05), and tended to attach to the atrial wall or valve instead of the atrial septum. Fever symptoms were more common in patients with malignant tumors than in patients with benign tumors (P < 0.05). Compared to benign tumor, patients with malignant atrial tumor also demonstrated higher rates of fever, lower rates of increasing fibrinogen, increased blood glucose (P < 0.05), significantly longer prothrombin time, and lower prothrombin activity (P < 0.05). Patients with malignant primary atrial tumor had higher mortality rate, tumor metastasis rate, and tumor recurrence rate than patients with benign primary atrial tumor (P < 0.05).

Conclusion: We compared the clinical characteristics of patients with benign and malignant atrial tumor. These findings provide valuable information to preoperatively determine the malignance of atrial tumor and thus guide surgical treatment.

Keywords: atrial tumor; cardiac; clinical characteristics; myxoma; primary tumor.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
distribution of primary cardiac tumors located in the atrium diagnosed and treated at division of cardiothoracic and vascular surgery of tongji hospital between 2012 and 2021.
Figure 2
Figure 2
Comparison of initial symptoms between patients with benign and malignant primary atrial tumors. ** represets P < 0.01.
Figure 3
Figure 3
Echocardiography and microbubble contrast-enhanced echocardiography images of patients with benign or malignant primary atrial tumor. (A) Echocardiography image of a patient with cardiac myxoma. (B) Microbubble contrast-enhanced echocardiography image of a patient with cardiac myxoma. (C) Echocardiography image of a patient with intimal sarcoma. (D) Microbubble contrast-enhanced echocardiography image of a patient with intimal sarcoma.
Figure 4
Figure 4
Pathological section images of patients with benign or malignant primary atrial tumor. (A) Cardiac myxoma. (B) Diffuse large B cell lymphoma. (C) Intimal sarcoma. (D) Angiosarcoma.
See this image and copyright information in PMC

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