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. 2022 Sep-Oct;67(5):624.
doi: 10.4103/ijd.ijd_917_20.

Assessment of Oxidative/Nitrosative Stress and Raftlin in Vitiligo

Mehmet K Mulayim  1 , Ergul B Kurutas  2 , Hulya Nazik  1 , Perihan Ozturk  1
Affiliations

Assessment of Oxidative/Nitrosative Stress and Raftlin in Vitiligo

Mehmet K Mulayim et al. Indian J Dermatol. 2022 Sep-Oct.

Abstract

Background: Vitiligo is a chronic skin disease characterized by white macules on the skin due to loss of melanocytes. Although there are many theories about the etiopathogenesis of the disease, oxidative stress is identified as an important determinant in the etiology of vitiligo. In recent years, Raftlin has been shown to play a role in many inflammatory diseases.

Aims: The aim of this study was to compare the patients with vitiligo and the control group to determine both oxidative/nitrosative stress markers and Raftlin levels.

Materials and methods: This study was designed prospectively between September 2017 and April 2018. Twenty-two patients diagnosed with vitiligo and 15 healthy people as the control group were included in the study. Blood samples collected to determine oxidative/nitrosative stress, the antioxidant enzyme, and Raftlin levels were sent to the biochemistry laboratory.

Results: In patients with vitiligo, the activities of catalase, superoxide dismutase, glutathione peroxidase, and glutathione S transferase were significantly lower than in the control group (P < 0.0001). In vitiligo patients, the levels of malondialdehyde, nitric oxide, nitrotyrosine (3-NTx), and Raftlin were significantly higher than in the control group (P < 0.0001).

Conclusions: The results of the study support that oxidative stress and nitrosative stress may play a role in the pathogenesis of vitiligo. In addition, the Raftlin level, a new biomarker of inflammatory diseases, was found high in patients with vitiligo.

Keywords: Nitrosative stress; oxidative stress; pathogenesis; raftlin; vitiligo.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
ROC curve for Raftlin area under the curve value of 0.979
Figure 2
Figure 2
ROC curve for malondialdehyde area under the curve value of 1.0
Figure 3
Figure 3
ROC curve for nitric oxide area under the curve value of 0.982
Figure 4
Figure 4
ROC curve for nitrotyrosine area under the curve value of 0.997
See this image and copyright information in PMC

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