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Case Reports
. 2023 Jan 29;15(1):e34344.
doi: 10.7759/cureus.34344. eCollection 2023 Jan.

Lysozyme-Induced Nephropathy: A Diagnosis Not to Forget

Núria Paulo  1 , Pedro Baptista  2 , Fernando Nogueira  3 , Catarina Pereira  3 , Ana Cerqueira  1   4 , Ana Rocha  1
Affiliations
Case Reports

Lysozyme-Induced Nephropathy: A Diagnosis Not to Forget

Núria Paulo et al. Cureus. .

Abstract

Kidney injury in hematologic malignancies can manifest in many ways. We present a case report of a 44-year-old female with de novo acute myeloid leukemia (AML) and acute kidney injury. Following the etiological investigation, lysozyme-induced nephropathy was believed to be the most probable cause of renal injury. Intensive cytoreduction and chemotherapy were started and the patient's cytopenias and kidney injury have improved. This case highlights the importance of recognizing lysozyme-induced nephropathy as a form of kidney injury in AML. Despite being frequently underrecognized, a precocious diagnosis may impact the patient's prognosis.

Keywords: acute kidney injury; case report; hematologic malignancies; lysozyme; lysozyme-induced nephropathy.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Evolution of serum creatinine and electrolytes during inpatient stay in relation to treatment.
See this image and copyright information in PMC

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