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Review
. 2023 Aug;71(8):1791-1803.
doi: 10.1002/glia.24353. Epub 2023 Mar 3.

The role of glial cells in Zika virus-induced neurodegeneration

André Quincozes-Santos  1   2   3 , Larissa Daniele Bobermin  2 , Naithan Ludian Fernandes Costa  2 , Natalie K Thomaz  3 , Rômulo Rodrigo de Souza Almeida  3 , Walter O Beys-da-Silva  4 , Lucélia Santi  4 , Rafael L Rosa  4 , Daniela Capra  5 , Juliana M Coelho-Aguiar  6 , Marcos Fabio DosSantos  7 , Manoela Heringer  5 , Elizabeth O Cirne-Lima  4 , Jorge Almeida Guimarães  4 , Lavínia Schuler-Faccini  4 , Carlos-Alberto Gonçalves  1   2   3 , Vivaldo Moura-Neto  5   6 , Diogo Onofre Souza  1   3
Affiliations
Review

The role of glial cells in Zika virus-induced neurodegeneration

André Quincozes-Santos et al. Glia. 2023 Aug.

Abstract

Zika virus (ZIKV) is a strongly neurotropic flavivirus whose infection has been associated with microcephaly in neonates. However, clinical and experimental evidence indicate that ZIKV also affects the adult nervous system. In this regard, in vitro and in vivo studies have shown the ability of ZIKV to infect glial cells. In the central nervous system (CNS), glial cells are represented by astrocytes, microglia, and oligodendrocytes. In contrast, the peripheral nervous system (PNS) constitutes a highly heterogeneous group of cells (Schwann cells, satellite glial cells, and enteric glial cells) spread through the body. These cells are critical in both physiological and pathological conditions; as such, ZIKV-induced glial dysfunctions can be associated with the development and progression of neurological complications, including those related to the adult and aging brain. This review will address the effects of ZIKV infection on CNS and PNS glial cells, focusing on cellular and molecular mechanisms, including changes in the inflammatory response, oxidative stress, mitochondrial dysfunction, Ca2+ and glutamate homeostasis, neural metabolism, and neuron-glia communication. Of note, preventive and therapeutic strategies that focus on glial cells may emerge to delay and/or prevent the development of ZIKV-induced neurodegeneration and its consequences.

Keywords: Zika virus; glial cells; inflammatory response; neurodegeneration; neuron-glia communication.

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References

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