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Review
. 2023 Dec;30(1):2183815.
doi: 10.1080/10717544.2023.2183815.

A detailed insight of the tumor targeting using nanocarrier drug delivery system

Sibgha Batool  1   2 , Saba Sohail  1   2 , Fakhar Ud Din  1   2 , Ali H Alamri  3 , Ahmad S Alqahtani  4 , Mohammad A Alshahrani  5 , Mohammed A Alshehri  6 , Han Gon Choi  7
Affiliations
Review

A detailed insight of the tumor targeting using nanocarrier drug delivery system

Sibgha Batool et al. Drug Deliv. 2023 Dec.

Abstract

Human struggle against the deadly disease conditions is continued since ages. The contribution of science and technology in fighting against these diseases cannot be ignored exclusively due to the invention of novel procedure and products, extending their size ranges from micro to nano. Recently nanotechnology has been gaining more consideration for its ability to diagnose and treat different cancers. Different nanoparticles have been used to evade the issues related with conservative anticancer delivery systems, including their nonspecificity, adverse effects and burst release. These nanocarriers including, solid lipid nanoparticles (SLNs), liposomes, nano lipid carriers (NLCs), nano micelles, nanocomposites, polymeric and magnetic nanocarriers, have brought revolutions in antitumor drug delivery. Nanocarriers improved the therapeutic efficacy of anticancer drugs with better accumulation at the specific site with sustained release, improved bioavailability and apoptosis of the cancer cells while bypassing the normal cells. In this review, the cancer targeting techniques and surface modification on nanoparticles are discussed briefly with possible challenges and opportunities. It can be concluded that understanding the role of nanomedicine in tumor treatment is significant, and therefore, the modern progressions in this arena is essential to be considered for a prosperous today and an affluent future of tumor patients.

Keywords: Tumor; drug delivery; nanotechnology; pharmaceutics; targeting.

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Conflict of interest statement

No potential conflict of interest was reported by the authors.

Figures

Figure 1.
Figure 1.
Graphical representation of the nanomedicine targeting tumor (Created with BioRender).
Figure 2.
Figure 2.
Illustration of the passive and active tumor targeting by nanoparticle (Created with BioRender).
Figure 3.
Figure 3.
Theranostic nanocarriers used in oncology (Created with BioRender).
Figure 4.
Figure 4.
Illustration of photothermal cancer therapy (Created with BioRender).
Figure 5.
Figure 5.
Mechanisms of photodynamic therapy (Created with BioRender).
See this image and copyright information in PMC

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