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Review
. 2023 Mar;52(3):196-205.
doi: 10.1007/s00132-023-04348-8. Epub 2023 Mar 3.

[Particle disease and its effects on periarticular tissue]

[Article in German]
Stefanie Donner  1 , Carsten Perka  2 , Veit Krenn  3 , Melanie-Jasmin Ort  4   5
Affiliations
Review

[Particle disease and its effects on periarticular tissue]

[Article in German]
Stefanie Donner et al. Orthopadie (Heidelb). 2023 Mar.

Abstract
in English, German

Particle disease is the condition caused by wear debris on surrounding tissues and influences the well-being of arthroplasty patients. This condition is multifactorial due to the type of bearing couple, head size and implant position. Subsequent periprosthetic osteolysis and soft tissue reactions, can lead to revision THA surgery. The periprosthetic synovial membrane (synovial-like interface membrane, SLIM) is used in diagnostics when the cause of implant failure is uncertain. Detailed analysis of synovial fluid and bone marrow could improve the diagnostic procedure and strengthen the cases for revision surgery and the underlying biology. A large number of research approaches on this topic have evolved and continue to be utilized in the clinic.

Die Abrieberkrankung beschreibt den Effekt des Implantatabriebs auf das umliegende Gewebe und das damit einhergehende Wohlbefinden des Patienten. Sie ist multifaktoriell durch die Art der Gleitpaarung, die Kopfgröße und die Implantatposition bedingt. Dies führt durch die Verursachung von periprothetischen Osteolysen und Weichgewebsreaktionen häufig zur Notwendigkeit einer Revisionsoperation der Hüft-TEP. Die periprothetische Synovialmembran („synovial-like interface membrane“ [SLIM]) spielt bei unsicherer Ursache des Implantatversagens in der Diagnostik eine wesentliche Rolle. Die dezidiertere Analyse der Synovialflüssigkeit und des Knochenmarks verbessert einerseits die Diagnostik, und andererseits das Verständnis für die Ursachen der Revisionsoperation, woraus sich eine Vielzahl von Forschungsansätzen entwickelt hat.

Keywords: Bone marrow; Immune response; Osteolysis; Particle size; Synovial membrane.

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References

Literatur

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