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Comparative Study
. 2024 Aug;32(4):811-819.
doi: 10.1177/17085381231160933. Epub 2023 Mar 3.

The results of thrombectomy from the arteries of the lower extremities in patients infected with SARS-CoV-2 Omicron variant with different severity of respiratory failure

Anton N Kazantsev  1 , Alina S Zharova  2 , Dmitriy V Shmatov  3 , Aslan B Zakeryaev  4 , Roman Yu Lider  5 , Elizaveta G Kazantseva  5 , Goderzi S Bagdavadze  2 , Alexander V Korotkikh  6 , Victor A Lutsenko  7 , Roman V Sultanov  7 , Oleg V Lebedev  1 , Alexey A Sirotkin  1 , Elena V Snopova  1 , Petr D Palagin  1
Affiliations
Comparative Study

The results of thrombectomy from the arteries of the lower extremities in patients infected with SARS-CoV-2 Omicron variant with different severity of respiratory failure

Anton N Kazantsev et al. Vascular. 2024 Aug.

Abstract

Goal: Analysis of the results of thrombectomy from the arteries of the lower extremities in patients with COVID-19 against the background of different severity of respiratory failure.

Materials and methods: This retrospective, cohort, comparative study for the period from 05/01/2022 to 20/07/2022 included 305 patients with acute thrombosis of the arteries of the lower extremities against the background of the course of COVID-19 (SARS-CoV-2 Omicron variant). Depending on the type of oxygen support, 3 groups of patients were formed: group 1 (n = 168) - oxygen insufflation through nasal cannulas; group 2 (n = 92) - non-invasive lung ventilation; and group 3 (n = 45) - artificial lung ventilation.

Results: Myocardial infarction and ischemic stroke were not detected in the total sample. The highest number of deaths (group 1: 5.3%, n = 9; group 2: 72.8%, n = 67; group 3: 100%, n = 45; p < 0.0001), rethrombosis (group 1 : 18.4%, n = 31; group 2: 69.5%, n = 64; group 3: 91.1%, n = 41; p < 0.0001), and limb amputations (group 1: 9.5%, n = 16; group 2: 56.5%, n = 52; group 3: 91.1%, n = 41; p < 0.0001) was recorded in group 3 (ventilated) patients.

Conclusion: In patients infected with COVID-19 and on artificial lung ventilation, a more aggressive course of the disease is noted, expressed in an increase in laboratory parameters (C-reactive protein, ferritin, interleukin-6, and D-dimer) of the degree of pneumonia (CT-4 in overwhelming number) and localization of thrombosis of the arteries of the lower extremities, mainly in the tibial arteries.

Keywords: COVID-19; SARS-CoV-2; acute lower limb ischemia; artificial lung ventilation; coagulopathy; coronavirus; endotheliitis; lower limb artery thrombosis; novel coronavirus; novel coronavirus infection; respiratory failure; thrombosis.

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Conflict of interest statement

Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Survival free from recurrent thrombosis in the postoperative period.
See this image and copyright information in PMC

References

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