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Comment
. 2023 Mar 2;83(5):653-654.
doi: 10.1016/j.molcel.2023.02.005.

The winding road toward transcriptional repression

Qingzhou Zhang  1 , Marjorie Brand  2
Affiliations
Comment

The winding road toward transcriptional repression

Qingzhou Zhang et al. Mol Cell. .

Abstract

Enhancers are known for their role in mediating transcriptional activation. In this issue, Vermunt et al.1 report the unexpected finding that genes can undergo a sequential transition between distinct enhancers to mediate progressive downregulation of expression.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Figures

Figure 1.
Figure 1.
An illustration of the mechanisms that gradually repress transcription via formation of an enhancer-like element within intronic regions of the targeted gene. Created with BioRender.com
See this image and copyright information in PMC

Comment on

References

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    1. Bartman CR, Hsu SC, Hsiung CC, Raj A, and Blobel GA (2016). Enhancer Regulation of Transcriptional Bursting Parameters Revealed by Forced Chromatin Looping. Mol Cell 62, 237–247. - PMC - PubMed
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