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Comment
. 2023 Mar 2;83(5):657-659.
doi: 10.1016/j.molcel.2023.01.025.

Dual-specificity RNA aptamers: A sweet new tool for studying O-GlcNAc biology

Steven S Cheng  1 , Christina M Woo  2
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Dual-specificity RNA aptamers: A sweet new tool for studying O-GlcNAc biology

Steven S Cheng et al. Mol Cell. .
Free article

Abstract

Zhu and Hart1 use dual-specificity RNA aptamers to recruit cellular O-GlcNAc transferase (OGT) and induce O-GlcNAc on target proteins like β-catenin, revealing that O-GlcNAc stabilizes β-catenin and enhances its transcriptional activity.

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Conflict of interest statement

Declaration of interests The Woo laboratory receives support from Ono Pharmaceuticals and Merck. The authors declare no other competing interests.

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