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Comment
. 2023 Mar 2;30(3):239-241.
doi: 10.1016/j.stem.2023.02.002.

Pandemic city: Village-in-a-dish unlocks dynamic genetic effects in the brain

Carina Seah  1 , Kristen J Brennand  2
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Free article
Comment

Pandemic city: Village-in-a-dish unlocks dynamic genetic effects in the brain

Carina Seah et al. Cell Stem Cell. .
Free article

Abstract

In this issue, Wells et al. combine genetic multiplexing ("village-in-a-dish") and Stem-cell-derived NGN2-accelerated Progenitors (SNaPs) to evaluate genotype-phenotype relationships across 100 donors in the context of Zika virus infection in the developing brain. This resource will be broadly applicable in uncovering how genetic variation underlies risk for neurodevelopmental disorders.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages.
    Wells MF, Nemesh J, Ghosh S, Mitchell JM, Salick MR, Mello CJ, Meyer D, Pietilainen O, Piccioni F, Guss EJ, Raghunathan K, Tegtmeyer M, Hawes D, Neumann A, Worringer KA, Ho D, Kommineni S, Chan K, Peterson BK, Raymond JJ, Gold JT, Siekmann MT, Zuccaro E, Nehme R, Kaykas A, Eggan K, McCarroll SA. Wells MF, et al. Cell Stem Cell. 2023 Mar 2;30(3):312-332.e13. doi: 10.1016/j.stem.2023.01.010. Epub 2023 Feb 15. Cell Stem Cell. 2023. PMID: 36796362 Free PMC article.

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