AMD recapitulated in a 3D biomimetic: A breakthrough in retina tissue engineering

Sonal Dalvi¹, Amit Chatterjee¹, Ruchira Singh²

Affiliations

¹ Department of Ophthalmology, University of Rochester, Rochester, NY 14620, USA; Center for Visual Science, University of Rochester, Rochester, NY 14620, USA.
² Department of Ophthalmology, University of Rochester, Rochester, NY 14620, USA; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14620, USA; Center for Visual Science, University of Rochester, Rochester, NY 14620, USA; UR Stem Cell and Regenerative Medicine Center, Rochester, NY 14620, USA. Electronic address: ruchira_singh@urmc.rochester.edu.

PMID: 36868191
DOI: 10.1016/j.stem.2023.02.001

Free article

Comment

AMD recapitulated in a 3D biomimetic: A breakthrough in retina tissue engineering

Sonal Dalvi et al. Cell Stem Cell. 2023.

Free article

. 2023 Mar 2;30(3):243-245.

doi: 10.1016/j.stem.2023.02.001.

Authors

Sonal Dalvi¹, Amit Chatterjee¹, Ruchira Singh²

Affiliations

¹ Department of Ophthalmology, University of Rochester, Rochester, NY 14620, USA; Center for Visual Science, University of Rochester, Rochester, NY 14620, USA.
² Department of Ophthalmology, University of Rochester, Rochester, NY 14620, USA; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14620, USA; Center for Visual Science, University of Rochester, Rochester, NY 14620, USA; UR Stem Cell and Regenerative Medicine Center, Rochester, NY 14620, USA. Electronic address: ruchira_singh@urmc.rochester.edu.

PMID: 36868191
DOI: 10.1016/j.stem.2023.02.001

Abstract

Song et al. (Nature Methods, 2022) engineered a 3D model of the human outer blood-retina barrier (oBRB) that recapitulates key features of healthy and age-related macular degeneration (AMD)-affected eyes.¹ We shine a spotlight on this tissue-engineering triumph that has the potential to transform preclinical studies of AMD and other eye diseases.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

Bioprinted 3D outer retina barrier uncovers RPE-dependent choroidal phenotype in advanced macular degeneration.
Song MJ, Quinn R, Nguyen E, Hampton C, Sharma R, Park TS, Koster C, Voss T, Tristan C, Weber C, Singh A, Dejene R, Bose D, Chen YC, Derr P, Derr K, Michael S, Barone F, Chen G, Boehm M, Maminishkis A, Singec I, Ferrer M, Bharti K. Song MJ, et al. Nat Methods. 2023 Jan;20(1):149-161. doi: 10.1038/s41592-022-01701-1. Epub 2022 Dec 22. Nat Methods. 2023. PMID: 36550275

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Elsevier Science
Other Literature Sources
- The Lens - Patent Citations Database
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

AMD recapitulated in a 3D biomimetic: A breakthrough in retina tissue engineering

Affiliations

AMD recapitulated in a 3D biomimetic: A breakthrough in retina tissue engineering

Authors

Affiliations

Abstract

Conflict of interest statement

Comment on

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical