Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 Mar 2;30(3):246-247.
doi: 10.1016/j.stem.2023.01.011.

Human stem cell models unravel mechanisms of somite segmentation

M Fethullah Simsek  1 , Ertuğrul M Özbudak  2
Affiliations
Free article
Comment

Human stem cell models unravel mechanisms of somite segmentation

M Fethullah Simsek et al. Cell Stem Cell. .
Free article

Abstract

In vitro models to study human somitogenesis, the formation of the segmented body plan, have so far been limited.1 Two papers in Nature now report the creation of pluripotent stem cell (PSC)-derived 3D culture systems that recapitulate the formation of somite-like structures and help gain insights into this developmental process.2,3.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Reconstruction and deconstruction of human somitogenesis in vitro.
    Miao Y, Djeffal Y, De Simone A, Zhu K, Lee JG, Lu Z, Silberfeld A, Rao J, Tarazona OA, Mongera A, Rigoni P, Diaz-Cuadros M, Song LMS, Di Talia S, Pourquié O. Miao Y, et al. Nature. 2023 Feb;614(7948):500-508. doi: 10.1038/s41586-022-05655-4. Epub 2022 Dec 21. Nature. 2023. PMID: 36543321 Free PMC article.
  • Reconstituting human somitogenesis in vitro.
    Yamanaka Y, Hamidi S, Yoshioka-Kobayashi K, Munira S, Sunadome K, Zhang Y, Kurokawa Y, Ericsson R, Mieda A, Thompson JL, Kerwin J, Lisgo S, Yamamoto T, Moris N, Martinez-Arias A, Tsujimura T, Alev C. Yamanaka Y, et al. Nature. 2023 Feb;614(7948):509-520. doi: 10.1038/s41586-022-05649-2. Epub 2022 Dec 21. Nature. 2023. PMID: 36543322

LinkOut - more resources