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Comment
. 2023 Apr 10;41(4):658-659.
doi: 10.1016/j.ccell.2023.02.006. Epub 2023 Mar 2.

T cell dynamism and immune-related adverse events

Douglas B Johnson  1 , Justin M Balko  2
Affiliations
Free article
Comment

T cell dynamism and immune-related adverse events

Douglas B Johnson et al. Cancer Cell. .
Free article

Abstract

Immune-related adverse events (irAEs) are a major complication of immune checkpoint inhibitors (ICIs) and occur in an unpredictable fashion. In a Med article, Nunez et al. profile peripheral blood markers in patients treated with ICIs, identifying that dynamic changes in proliferating T cells and cytokine upregulation are associated with irAEs.

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Conflict of interest statement

Declaration of interests D.B.J. has served on advisory boards or as a consultant for Bristol Myers Squibb (BMS), Catalyst Biopharma, Iovance, Jansen, Mallinckrodt, Merck, Mosaic ImmunoEngineering, Novartis, Oncosec, Pfizer, and Targovax and has received research funding from BMS and Incyte. J.M.B. receives research support from Genentech/Roche and Incyte Corporation, has received advisory board payments from AstraZeneca and Mallinckrodt, and is an inventor on patents regarding immunotherapy targets and biomarkers in cancer.

Comment on

  • Immune signatures predict development of autoimmune toxicity in patients with cancer treated with immune checkpoint inhibitors.
    Nuñez NG, Berner F, Friebel E, Unger S, Wyss N, Gomez JM, Purde MT, Niederer R, Porsch M, Lichtensteiger C, Kramer R, Erdmann M, Schmitt C, Heinzerling L, Abdou MT, Karbach J, Schadendorf D, Zimmer L, Ugurel S, Klümper N, Hölzel M, Power L, Kreutmair S, Capone M, Madonna G, Cevhertas L, Heider A, Amaral T, Hasan Ali O, Bomze D, Dimitriou F, Diem S, Ascierto PA, Dummer R, Jäger E, Driessen C, Levesque MP, van de Veen W, Joerger M, Früh M, Becher B, Flatz L. Nuñez NG, et al. Med. 2023 Feb 10;4(2):113-129.e7. doi: 10.1016/j.medj.2022.12.007. Epub 2023 Jan 23. Med. 2023. PMID: 36693381

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