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Case Reports
. 2023 Mar;11(5):e15617.
doi: 10.14814/phy2.15617.

Profound hyponatremia and dehydration: A case of cisplatin induced renal salt wasting syndrome

Tissa Bijoy George  1 , Kiran Kuriakose  2 , Anjana Chandrasekhara Pillai  1 , Thomas Powell  3 , Thomas R Kleyman  4
Affiliations
Case Reports

Profound hyponatremia and dehydration: A case of cisplatin induced renal salt wasting syndrome

Tissa Bijoy George et al. Physiol Rep. 2023 Mar.

Abstract

Cisplatin is a well-known chemotherapeutic agent that can be associated with hyponatremia. It is known to be associated with a multitude of renal disorders including acute kidney injury with reduced glomerular filtration, Fanconi syndrome, and renal tubular acidosis, nephrogenic diabetes insipidus and renal salt wasting syndrome. We report a case of an elderly male presenting with significant recurrent hyponatremia, and prerenal azotemia. With recent exposure to cisplatin along with significant hypovolemia and urinary loss of sodium, he was diagnosed to have cisplatin induced renal salt wasting syndrome.

Keywords: cisplatin; hyponatremia; renal salt wasting.

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Conflict of interest statement

The authors have no conflict of interest to declare.

Figures

FIGURE 1
FIGURE 1
Trends in sodium, creatinine, bicarbonate levels.
See this image and copyright information in PMC

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