Neonatal Opioid Withdrawal Syndrome: An Update on Developmental Outcomes
- PMID: 36868704
- DOI: 10.1016/j.clp.2022.10.007
Neonatal Opioid Withdrawal Syndrome: An Update on Developmental Outcomes
Abstract
Infants and children with prenatal opioid exposure generally have development within the normal range; however, they seem to be at risk for behavioral problems and for lower scores on cognitive, language, and motor assessments than children without prenatal opioid exposure. It is as of yet unclear whether prenatal opioid exposure itself causes issues with development and behavior, or whether it is simply correlated, due to other confounding factors.
Keywords: Developmental outcomes; Neonatal abstinence syndrome (NAS); Neonatal opioid withdrawal syndrome (NOWS); Neurodevelopment; Opioid.
Copyright © 2022 Elsevier Inc. All rights reserved.
Conflict of interest statement
Disclosure The authors have nothing to disclose.
Similar articles
-
Reconceptualizing non-pharmacologic approaches to Neonatal Abstinence Syndrome (NAS) and Neonatal Opioid Withdrawal Syndrome (NOWS): A theoretical and evidence-based approach. Part II: The clinical application of nonpharmacologic care for NAS/NOWS.Neurotoxicol Teratol. 2021 Nov-Dec;88:107032. doi: 10.1016/j.ntt.2021.107032. Epub 2021 Sep 29. Neurotoxicol Teratol. 2021. PMID: 34600100 Review.
-
Reconceptualizing non-pharmacologic approaches to Neonatal Abstinence Syndrome (NAS) and Neonatal Opioid Withdrawal Syndrome (NOWS): A theoretical and evidence-based approach.Neurotoxicol Teratol. 2021 Nov-Dec;88:107020. doi: 10.1016/j.ntt.2021.107020. Epub 2021 Aug 19. Neurotoxicol Teratol. 2021. PMID: 34419619 Free PMC article. Review.
-
Association between prenatal opioid exposure, neonatal opioid withdrawal syndrome, and neurodevelopmental and behavioral outcomes at 5-8 months of age.Early Hum Dev. 2019 Jan;128:69-76. doi: 10.1016/j.earlhumdev.2018.10.010. Epub 2018 Dec 13. Early Hum Dev. 2019. PMID: 30554024 Free PMC article.
-
Prenatal Opioid Exposure, Neonatal Abstinence Syndrome/Neonatal Opioid Withdrawal Syndrome, and Later Child Development Research: Shortcomings and Solutions.J Addict Med. 2019 Mar/Apr;13(2):90-92. doi: 10.1097/ADM.0000000000000463. J Addict Med. 2019. PMID: 30334926
-
Neonatal sleep development and early learning in infants with prenatal opioid exposure.Adv Child Dev Behav. 2021;60:199-228. doi: 10.1016/bs.acdb.2020.07.001. Epub 2020 Sep 15. Adv Child Dev Behav. 2021. PMID: 33641794
Cited by
-
Neurobehavioral Profiles in Opioid-Exposed and Unexposed Neonates.J Pediatr. 2025 Jun;281:114527. doi: 10.1016/j.jpeds.2025.114527. Epub 2025 Mar 7. J Pediatr. 2025. PMID: 40057022
-
Early childhood growth following prenatal opioid exposure and Neonatal Opioid Withdrawal Syndrome.Pediatr Res. 2025 Mar 27. doi: 10.1038/s41390-025-04006-z. Online ahead of print. Pediatr Res. 2025. PMID: 40148475
-
Molecular and long-term behavioral consequences of neonatal opioid exposure and withdrawal in mice.Front Behav Neurosci. 2023 Jun 21;17:1202099. doi: 10.3389/fnbeh.2023.1202099. eCollection 2023. Front Behav Neurosci. 2023. PMID: 37424750 Free PMC article.
-
Advances in the Care of Infants With Prenatal Opioid Exposure and Neonatal Opioid Withdrawal Syndrome.Pediatrics. 2024 Jan 1;153(2):e2023062871. doi: 10.1542/peds.2023-062871. Pediatrics. 2024. PMID: 38178779 Free PMC article. Review.
-
Well-Child Visits and Immunization Encounters in South Carolina Medicaid: A 3-Year Retrospective Comparison Between Rural and Urban Children with a History of Neonatal Opioid Withdrawal Syndrome, 2006-2014.Healthcare (Basel). 2025 Jun 27;13(13):1539. doi: 10.3390/healthcare13131539. Healthcare (Basel). 2025. PMID: 40648564 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources