Letter to the Editor: The pathological impact of PAR2 on hepatic insulin resistance

Hsien-Hui Chung^{1

2

3}

Affiliations

¹ Department of Pharmacy & Clinical Trial Pharmacy, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan.
² Preventive Medicine Program, Center for General Education, Chung Yuan Christian University, Taoyuan City, Taiwan.
³ Department of Pharmacy and Master Program, College of Pharmacy and Health Care, Tajen University, Pingtung County, Taiwan.

Comment

Hsien-Hui Chung. Hepatology. 2023.

. 2023 May 1;77(5):E109-E110.

doi: 10.1097/HEP.0000000000000284. Epub 2023 Jan 3.

Hsien-Hui Chung^{1

2

3}

¹ Department of Pharmacy & Clinical Trial Pharmacy, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan.
² Preventive Medicine Program, Center for General Education, Chung Yuan Christian University, Taoyuan City, Taiwan.
³ Department of Pharmacy and Master Program, College of Pharmacy and Health Care, Tajen University, Pingtung County, Taiwan.

No abstract available

Comment on

PAR2 promotes impaired glucose uptake and insulin resistance in NAFLD through GLUT2 and Akt interference.
Shearer AM, Wang Y, Fletcher EK, Rana R, Michael ES, Nguyen N, Abdelmalek MF, Covic L, Kuliopulos A. Shearer AM, et al. Hepatology. 2022 Dec;76(6):1778-1793. doi: 10.1002/hep.32589. Epub 2022 Jun 11. Hepatology. 2022. PMID: 35603482 Free PMC article.

1. Shearer AM, Wang Y, Fletcher EK, Rana R, Michael ES, Nguyen N, et al. PAR2 promotes impaired glucose uptake and insulin resistance in NAFLD through GLUT2 and Akt interference. Hepatology. 2022;76:1778–93.
1. Wang J, Chakrabarty S, Bui Q, Ruf W, Samad F. Hematopoietic tissue factor-protease-activated receptor 2 signaling promotes hepatic inflammation and contributes to pathways of gluconeogenesis and steatosis in obese mice. Am J Pathol. 2015;185:524–35.
1. Lim J, Iyer A, Liu L, Suen JY, Lohman RJ, Seow V, et al. Diet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism. FASEB J. 2013;27:4757–67.
1. Kim BM, Kim DH, Park YJ, Ha S, Choi YJ, Yu HS, et al. PAR2 promotes high-fat diet-induced hepatic steatosis by inhibiting AMPK-mediated autophagy. J Nutr Biochem. 2021;95:108769.