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Editorial
. 2023 Dec 5;29(12):2003-2005.
doi: 10.1093/ibd/izad027.

Shedding New Light on High-Risk Phenotypes for Pouchitis

Edward L Barnes  1   2   3 , Shannon Chang  4
Affiliations
Editorial

Shedding New Light on High-Risk Phenotypes for Pouchitis

Edward L Barnes et al. Inflamm Bowel Dis. .
No abstract available

Keywords: ileal pouch-anal anastomosis; pouchitis; risk-stratification; ulcerative colitis.

Plain language summary

Identifying those patients at the greatest risk for pouchitis at the time of ileal pouch-anal anastomosis for ulcerative colitis remains a challenge. We discuss the importance of this topic by reviewing recent data regarding the impact of acute severe ulcerative colitis on risk of pouchitis and the implications for future clinical decisions and studies of risk stratification.

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Conflict of interest statement

E.L.B. has served as a consultant for AbbVie, Bristol-Meyers Squibb, Lilly, and Target RWE.

S.C. has served as a consultant for AbbVie, Bristol-Meyers Squibb, and Pfizer.

Comment on

References

    1. Barnes EL, Herfarth HH, Kappelman MD, et al. . Incidence, risk factors, and outcomes of pouchitis and pouch-related complications in patients with ulcerative colitis. Clin Gastroenterol Hepatol. 2021;19:1583-1591.e4. - PMC - PubMed
    1. Barnes EL, Allin KH, Iversen AT, Herfarth HH, Jess T.. Increasing incidence of pouchitis between 1996 and 2018: a population-based danish cohort study. Clin Gastroenterol Hepatol. 2023;21:192-199.e7. - PMC - PubMed
    1. Lightner AL, Mathis KL, Dozois EJ, et al. . Results at up to 30 years after ileal pouch-anal anastomosis for chronic ulcerative colitis. Inflamm Bowel Dis. 2017;23:781-790. - PubMed
    1. Fazio VW, Kiran RP, Remzi FH, et al. . Ileal pouch anal anastomosis: analysis of outcome and quality of life in 3707 patients. Ann Surg. 2013;257:679-685. - PubMed
    1. Barnes EL, Holubar SD, Herfarth HH.. Systematic review and meta-analysis of outcomes after ileal pouch-anal anastomosis in primary sclerosing cholangitis-ulcerative colitis. J Crohns Colitis 2021;15:1272-1278. - PubMed

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