The evolving use of biomarkers in heart transplantation: Consensus of an expert panel

Collaborators, Affiliations

Collaborators

conference participants:
Jon Kobashigawa¹⁰, Shelly Hall¹¹, Sean Agbor-Enoh¹², Robert Bray¹³, Martin Cadeiras¹⁴, Patty Chang¹⁵, Sharon Chih¹⁶, Howie Eisen¹⁷, Maryjane Farr¹⁸, Barry Fine¹⁹, Kambiz Ghafourian²⁰, Phil Halloran²¹, Annette M Jackson²², Andrew Kao²³, Kiran K Khush²⁴, Anant Madabhushi²⁵, Kenneth B Margulies²⁶, Maryam Mojarrad Sani²⁷, Jignesh K Patel²⁷, Nikhil Patel²⁷, Eliot Peyster²⁶, Anil Parwani²⁸, Sean Pinney²⁹, Kelley Schlendorf³⁰, Keyur Shah³¹, Palak Shah³², Josef Stehlik³³, Anat Tambur³⁴, Adriana Zeevi³⁵

Affiliations

¹ Department of Cardiology, Cedars-Sinai Smidt Heart Institute, Los Angeles, California, USA. Electronic address: kobashigawaj@cshs.org.
² Department of Cardiology, Baylor University Medical Center, Dallas, Texas, USA.
³ Department of Cardiology, Inova Heart and Vascular Institute, Falls Church, Virginia, USA.
⁴ Department of Cardiology, Columbia University Irving Medical Center, New York, USA.
⁵ Department of Medicine Division of Nephrology, University of Alberta, Edmonton, Canada.
⁶ Department of Surgery, Duke University, Durham, North Carolina, USA; Department of Immunology, Duke University, Durham, North Carolina, USA.
⁷ Department of Medicine, Stanford University, Stanford, California, USA.
⁸ Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
⁹ Department of Cardiology, Cedars-Sinai Smidt Heart Institute, Los Angeles, California, USA.
¹⁰ Chair, Cedars-Sinai Smidt Heart Institute, Los Angeles, CA.
¹¹ Co-Chair, Baylor University Medical Center, Dallas, TX.
¹² Johns Hopkins Medical school, Baltimore, MD.
¹³ Emory University, Atlanta, GA.
¹⁴ UC Davis Health System, CA.
¹⁵ University of North Carolina at Chapel Hill, NC.
¹⁶ University of Ottawa Heart Institute, Ottawa, Canada.
¹⁷ Penn State Health Milton S. Hershey Medical Center, Hershey, PA.
¹⁸ UT Southwestern, Dallas, TX.
¹⁹ Columbia University Irving Medical Center, New York, NY.
²⁰ Northwestern Memorial Hospital, Chicago, IL.
²¹ University of Alberta, Edmonton, Canada.
²² Duke University, Durham, NC.
²³ Saint Luke's Mid America Heart Institute, Kansas City, MO.
²⁴ Stanford University, Stanford, CA.
²⁵ Case Western Reserve University School of Medicine, Cleveland, OH.
²⁶ University of Pennsylvania, Philadelphia, PA.
²⁷ Cedars-Sinai Smidt Heart Institute, Los Angeles, CA.
²⁸ Ohio State University, Columbus, OH.
²⁹ University of Chicago, Chicago, IL.
³⁰ Vanderbilt University Medical Center, Nashville, Tennessee.
³¹ VCU school of medicine, Richmond, VA.
³² Inova Fairfax Hospital, Falls Church, VA.
³³ University of Utah, Salt Lake City, UT.
³⁴ Northwestern university, Chicago, IL.
³⁵ University of Pittsburgh, Pittsburgh, PA.

PMID: 36870390
PMCID: PMC10387364
DOI: 10.1016/j.ajt.2023.02.025

Review

The evolving use of biomarkers in heart transplantation: Consensus of an expert panel

Jon Kobashigawa et al. Am J Transplant. 2023 Jun.

. 2023 Jun;23(6):727-735.

doi: 10.1016/j.ajt.2023.02.025. Epub 2023 Mar 3.

Authors

Collaborators

conference participants:
Jon Kobashigawa¹⁰, Shelly Hall¹¹, Sean Agbor-Enoh¹², Robert Bray¹³, Martin Cadeiras¹⁴, Patty Chang¹⁵, Sharon Chih¹⁶, Howie Eisen¹⁷, Maryjane Farr¹⁸, Barry Fine¹⁹, Kambiz Ghafourian²⁰, Phil Halloran²¹, Annette M Jackson²², Andrew Kao²³, Kiran K Khush²⁴, Anant Madabhushi²⁵, Kenneth B Margulies²⁶, Maryam Mojarrad Sani²⁷, Jignesh K Patel²⁷, Nikhil Patel²⁷, Eliot Peyster²⁶, Anil Parwani²⁸, Sean Pinney²⁹, Kelley Schlendorf³⁰, Keyur Shah³¹, Palak Shah³², Josef Stehlik³³, Anat Tambur³⁴, Adriana Zeevi³⁵

Affiliations

¹ Department of Cardiology, Cedars-Sinai Smidt Heart Institute, Los Angeles, California, USA. Electronic address: kobashigawaj@cshs.org.
² Department of Cardiology, Baylor University Medical Center, Dallas, Texas, USA.
³ Department of Cardiology, Inova Heart and Vascular Institute, Falls Church, Virginia, USA.
⁴ Department of Cardiology, Columbia University Irving Medical Center, New York, USA.
⁵ Department of Medicine Division of Nephrology, University of Alberta, Edmonton, Canada.
⁶ Department of Surgery, Duke University, Durham, North Carolina, USA; Department of Immunology, Duke University, Durham, North Carolina, USA.
⁷ Department of Medicine, Stanford University, Stanford, California, USA.
⁸ Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
⁹ Department of Cardiology, Cedars-Sinai Smidt Heart Institute, Los Angeles, California, USA.
¹⁰ Chair, Cedars-Sinai Smidt Heart Institute, Los Angeles, CA.
¹¹ Co-Chair, Baylor University Medical Center, Dallas, TX.
¹² Johns Hopkins Medical school, Baltimore, MD.
¹³ Emory University, Atlanta, GA.
¹⁴ UC Davis Health System, CA.
¹⁵ University of North Carolina at Chapel Hill, NC.
¹⁶ University of Ottawa Heart Institute, Ottawa, Canada.
¹⁷ Penn State Health Milton S. Hershey Medical Center, Hershey, PA.
¹⁸ UT Southwestern, Dallas, TX.
¹⁹ Columbia University Irving Medical Center, New York, NY.
²⁰ Northwestern Memorial Hospital, Chicago, IL.
²¹ University of Alberta, Edmonton, Canada.
²² Duke University, Durham, NC.
²³ Saint Luke's Mid America Heart Institute, Kansas City, MO.
²⁴ Stanford University, Stanford, CA.
²⁵ Case Western Reserve University School of Medicine, Cleveland, OH.
²⁶ University of Pennsylvania, Philadelphia, PA.
²⁷ Cedars-Sinai Smidt Heart Institute, Los Angeles, CA.
²⁸ Ohio State University, Columbus, OH.
²⁹ University of Chicago, Chicago, IL.
³⁰ Vanderbilt University Medical Center, Nashville, Tennessee.
³¹ VCU school of medicine, Richmond, VA.
³² Inova Fairfax Hospital, Falls Church, VA.
³³ University of Utah, Salt Lake City, UT.
³⁴ Northwestern university, Chicago, IL.
³⁵ University of Pittsburgh, Pittsburgh, PA.

PMID: 36870390
PMCID: PMC10387364
DOI: 10.1016/j.ajt.2023.02.025

Abstract

In heart transplantation, the use of biomarkers to detect the risk of rejection has been evolving. In this setting, it is becoming less clear as to what is the most reliable test or combination of tests to detect rejection and assess the state of the alloimmune response. Therefore, a virtual expert panel was organized in heart and kidney transplantation to evaluate emerging diagnostics and how they may be best utilized to monitor and manage transplant patients. This manuscript covers the heart content of the conference and is a work product of the American Society of Transplantation's Thoracic and Critical Care Community of Practice. This paper reviews currently available and emerging diagnostic assays and defines the unmet needs for biomarkers in heart transplantation. Highlights of the in-depth discussions among conference participants that led to development of consensus statements are included. This conference should serve as a platform to further build consensus within the heart transplant community regarding the optimal framework to implement biomarkers into management protocols and to improve biomarker development, validation and clinical utility. Ultimately, these biomarkers and novel diagnostics should improve outcomes and optimize quality of life for our transplant patients.

Keywords: biomarkers; donor-derived cell-free deoxyribonucleic acid; genomics; heart transplantation; machine learning; microRNA; outcomes.

PubMed Disclaimer

Conflict of interest statement

Disclosure

The authors of this manuscript have no conflicts of interest to disclose as described by the American Journal of Transplantation.

References

1. Crespo–Leiro MG, Zuckermann A, Bara C, et al. Concordance among pathologists in the second Cardiac Allograft Rejection Gene Expression Observational Study (CARGO II). Transplantation. 2012;94(11):1172–1177. - PubMed
1. Barten MJ, Schulz U, Beiras-Fernandez A, et al. The clinical impact of donor-specific antibodies in heart transplantation. Transplant Rev (Orlando). 2018;32(4):207–217. - PubMed
1. Zhang Q, Hickey M, Drogalis–Kim D, et al. Understanding the correlation between DSA, complement activation, and antibody-mediated rejection in heart transplant recipients. Transplantation. 2018;102(10):e431–e438. - PMC - PubMed
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1. Tran A, Fixler D, Huang R, Meza T, Lacelle C, Das BB. Donor-specific HLA alloantibodies: impact on cardiac allograft vasculopathy, rejection, and survival after pediatric heart transplantation. J Heart Lung Transplant. 2016;35(1):87–91. - PubMed

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The evolving use of biomarkers in heart transplantation: Consensus of an expert panel

Collaborators

Affiliations

The evolving use of biomarkers in heart transplantation: Consensus of an expert panel

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

References

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