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. 2023 Apr;47(3):263-271.e1.
doi: 10.1016/j.jcjd.2023.02.002. Epub 2023 Feb 11.

Canadian Cystic Fibrosis-related Diabetes Clinical Practice Survey: Analysis of Current Practices and Gaps in Clinical Care

Kathryn J Potter  1 , Adèle Coriati  2 , Patrick Hicks  3 , Larry C Lands  4 , Martha L McKinney  3 , Valérie Boudreau  1 , Anne Bonhoure  1 , Paola Luca  5 , Josephine Ho  5 , Sémah Tagougui  6 , Amanda Jober  3 , Meghan Pohl  3 , Elizabeth T Rosolowsky  7 , Julie Gilmour  8 , Grace Y Lam  9 , Anne L Stephenson  10 , Peter A Senior  11 , Rémi Rabasa-Lhoret  12 , Tamizan Kherani  3
Affiliations

Canadian Cystic Fibrosis-related Diabetes Clinical Practice Survey: Analysis of Current Practices and Gaps in Clinical Care

Kathryn J Potter et al. Can J Diabetes. 2023 Apr.

Abstract

Objectives: Our aim in this study was to identify challenges and gaps in Canadian practices in screening, diagnosis, and treatment of cystic fibrosis-related diabetes (CFRD), with the goal of informing a Canadian-specific guideline for CFRD.

Methods: We conducted an online survey of health-care professionals (97 physicians and 44 allied health professionals) who care for people living with CF (pwCF) and/or CFRD (pwCFRD).

Results: Most pediatric centres followed <10 pwCFRD and adult centres followed >10 pwCFRD. Children with CFRD are usually followed at a separate diabetes clinic, whereas adults with CFRD may be followed by respirologists, nurse practitioners, or endocrinologists in a CF clinic or in a separate diabetes clinic. Less than 25% of pwCF had access to an endocrinologist with a special interest or expertise in CFRD. Many centres perform screening oral glucose tolerance testing with fasting and 2-hour time points. Respondents, especially those working with adults, also indicate use of additional tests for screening not currently recommended in CFRD guidelines. Pediatric practitioners tend to only use insulin to manage CFRD, whereas adult practitioners are more likely to use repaglinide as an alternative to insulin.

Conclusions: Access to specialized CFRD care may be a challenge for pwCFRD in Canada. There appears to be wide heterogeneity of CFRD care organization, screening, and treatment among health-care providers caring for pwCF and/or pwCFRD across Canada. Practitioners working with adult pwCF are less likely to adhere to current clinical practice guidelines than practitioners working with children.

Keywords: A1C; CF; CFRD; DLFK; FK; HGPO; HbA1c; OGTT; clinical practice survey; cystic fibrosis; cystic fibrosis–related diabetes; diabéte lié á la fibrose kystique; dépistage; efibrose kystique; enquête sur la pratique clinique; oral glucose tolerance test; screening; traitement; treatment; épreuve de l'hyperglycémie provoquée par voie orale.

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