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. 2023 Jan;16(1):52-61.
doi: 10.25122/jml-2022-0049.

Effect of commercially pure titanium implant coated with calcium carbonate and nanohydroxyapatite mixture on osseointegration

Zainab Saleh Abdullah  1 , Mustafa Shaker Mahmood  1 , Faiza Mohammed Ali Abdul-Ameer  1 , Abdalbseet Ahmad Fatalla  1
Affiliations

Effect of commercially pure titanium implant coated with calcium carbonate and nanohydroxyapatite mixture on osseointegration

Zainab Saleh Abdullah et al. J Med Life. 2023 Jan.

Abstract

In this research, rabbit femurs were implanted with CP Ti screws coated with a combination of CaCO3 and nanohydroxyapatite, and the effect on osseointegration was assessed using histological and histomorphometric examination at 2 and 6 weeks. CaCO3 and nanohydroxyapatite were combined with the EPD to coat the surfaces of the CP Ti screws. The femurs of five male rabbits were implanted with coated and uncoated implant screws. Healing time was divided into two groups (2 and 6 weeks). After 2 and 6 weeks of implantation, the histological examination revealed an increase in the growth of bone cells for coated screws, and the histomorphometric analysis revealed an increase in the percentage of new bone formation (after 6 weeks, 5.08% for coated implants and 3.66% for uncoated implants). In addition, the uncoated implant, the CP Ti implant coated with a combination of CaCO3 and nanohydroxyapatite, stimulated early bone development after two weeks and mineralization and maturation after six weeks.

Keywords: calcium carbonate; electrophoretic; histomorphometric; nanohydroxyapatite; osseointegration.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Coated and uncoated implants in position.
Figure 2
Figure 2
Measuring the section diameter.
Figure 3
Figure 3
New bone area tracing.
Figure 4
Figure 4
Microscopic view of the uncoated implant in the thread area of rabbit femur two weeks after implantation (H&E stain) 4x. A: Control; B: Coated.
Figure 5
Figure 5
Microscopic view of the uncoated implant in the thread area of rabbit femur two weeks after implantation (H&E stain) 20x. A: Control; B: Coated.
Figure 6
Figure 6
Microscopic view of the uncoated implant in the thread area of rabbit femur six weeks after implantation (H&E stain) 4x. A: Control; B: Coated.
Figure 7
Figure 7
Microscopic view of the uncoated implant in the thread area of rabbit femur six weeks after implantation (H&E stain) 20x. A: Control; B: Coated.
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