Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Feb 16:14:1065812.
doi: 10.3389/fpsyt.2023.1065812. eCollection 2023.

Therapies for obsessive-compulsive disorder: Current state of the art and perspectives for approaching treatment-resistant patients

Kevin Swierkosz-Lenart  1 , Joao Flores Alves Dos Santos  2 , Julien Elowe  3   4 , Anne-Hélène Clair  5 , Julien F Bally  6 , Françoise Riquier  7 , Jocelyne Bloch  7 , Bogdan Draganski  8   9 , Marie-Thérèse Clerc  1 , Beatriz Pozuelo Moyano  1 , Armin von Gunten  1 , Luc Mallet  2   10   11
Affiliations
Review

Therapies for obsessive-compulsive disorder: Current state of the art and perspectives for approaching treatment-resistant patients

Kevin Swierkosz-Lenart et al. Front Psychiatry. .

Abstract

Even though obsessive compulsive disorder (OCD) is one of the ten most disabling diseases according to the WHO, only 30-40% of patients suffering from OCD seek specialized treatment. The currently available psychotherapeutic and pharmacological approaches, when properly applied, prove ineffective in about 10% of cases. The use of neuromodulation techniques, especially Deep Brain Stimulation, is highly promising for these clinical pictures and knowledge in this domain is constantly evolving. The aim of this paper is to provide a summary of the current knowledge about OCD treatment, while also discussing the more recent proposals for defining resistance.

Keywords: deep brain stimulation; neuromodulation; obsessive-compulsive disorder; refractory; resistant.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
A schematic summary of the various treatment steps according to the best evidence in the literature.
See this image and copyright information in PMC

References

    1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Washington, DC: American Psychiatric Association; (2013).
    1. Murray C, Lopez A. The global burden of diseases: a comprehensive assessment of mortality and disability from diseases, injuries and risk factors in 1990 and projected to 2020. Boston: Harvard School of Public Health; (1996). 325 p.
    1. Ruscio AM, Stein DJ, Chiu WT, Kessler RC. The epidemiology of obsessive-compulsive disorder in the national comorbidity survey replication. Mol Psychiatry. (2010) 15:53–63. - PMC - PubMed
    1. Fullana M, Vilagut G, Rojas-Farreras S, Mataix-Cols D, de Graaf R, Demyttenaere K, et al. Obsessive-compulsive symptom dimensions in the general population: results from an epidemiological study in six European countries. J Affect Disord. (2010) 124:291–9. 10.1016/j.jad.2009.11.020 - DOI - PubMed
    1. Belloch A, Del Valle G, Morillo C, Carrió C, Cabedo E. To seek advice or not to seek advice about the problem: the help-seeking dilemma for obsessive-compulsive disorder. Soc Psychiatry Psychiatr Epidemiol. (2009) 44:257–64. 10.1007/s00127-008-0423-0 - DOI - PubMed

LinkOut - more resources