Capturing the multifaceted function of adipose tissue macrophages
- PMID: 36875144
- PMCID: PMC9977801
- DOI: 10.3389/fimmu.2023.1148188
Capturing the multifaceted function of adipose tissue macrophages
Abstract
Adipose tissue macrophages (ATMs) bolster obesity-induced metabolic dysfunction and represent a targetable population to lessen obesity-associated health risks. However, ATMs also facilitate adipose tissue function through multiple actions, including adipocyte clearance, lipid scavenging and metabolism, extracellular remodeling, and supporting angiogenesis and adipogenesis. Thus, high-resolution methods are needed to capture macrophages' dynamic and multifaceted functions in adipose tissue. Herein, we review current knowledge on regulatory networks critical to macrophage plasticity and their multifaceted response in the complex adipose tissue microenvironment.
Keywords: adipose tissue; immune response; macrophage; obesity; single-cell RNA sequencing.
Copyright © 2023 Matz, Qu, Karlinsey, Vella and Zhou.
Conflict of interest statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Figures

Similar articles
-
MicroRNA-10a-5p regulates macrophage polarization and promotes therapeutic adipose tissue remodeling.Mol Metab. 2019 Nov;29:86-98. doi: 10.1016/j.molmet.2019.08.015. Epub 2019 Aug 27. Mol Metab. 2019. PMID: 31668395 Free PMC article.
-
How obesity affects adipocyte turnover.Trends Endocrinol Metab. 2025 Feb;36(2):147-160. doi: 10.1016/j.tem.2024.07.004. Epub 2024 Aug 1. Trends Endocrinol Metab. 2025. PMID: 39095230 Review.
-
The contribution of arachidonate 15-lipoxygenase in tissue macrophages to adipose tissue remodeling.Cell Death Dis. 2016 Jun 30;7(6):e2285. doi: 10.1038/cddis.2016.190. Cell Death Dis. 2016. PMID: 27362803 Free PMC article.
-
Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses.Diabetologia. 2018 Apr;61(4):942-953. doi: 10.1007/s00125-017-4526-6. Epub 2018 Jan 14. Diabetologia. 2018. PMID: 29333574 Free PMC article.
-
Adipocyte-Macrophage Cross-Talk in Obesity.Adv Exp Med Biol. 2017;960:327-343. doi: 10.1007/978-3-319-48382-5_14. Adv Exp Med Biol. 2017. PMID: 28585206 Review.
Cited by
-
The Impact of Resident Adipose Tissue Macrophages on Adipocyte Homeostasis and Dedifferentiation.Int J Mol Sci. 2024 Dec 4;25(23):13019. doi: 10.3390/ijms252313019. Int J Mol Sci. 2024. PMID: 39684730 Free PMC article.
-
Emerging Advancements in Metabolic Properties of Macrophages within Disease Microenvironment for Immune Therapy.J Innate Immun. 2025;17(1):320-340. doi: 10.1159/000546476. Epub 2025 Jun 11. J Innate Immun. 2025. PMID: 40499523 Free PMC article. Review.
-
Animal-Free Setup of a 3D Mature Adipocyte-Macrophage Co-Culture to Induce Inflammation In Vitro.Adv Healthc Mater. 2025 Aug;14(22):e2500779. doi: 10.1002/adhm.202500779. Epub 2025 Jun 20. Adv Healthc Mater. 2025. PMID: 40538298 Free PMC article.
-
From the Sun to the Cell: Examining Obesity through the Lens of Vitamin D and Inflammation.Metabolites. 2023 Dec 20;14(1):4. doi: 10.3390/metabo14010004. Metabolites. 2023. PMID: 38276294 Free PMC article. Review.
-
The Interplay between Immune and Metabolic Pathways in Kidney Disease.Cells. 2023 Jun 8;12(12):1584. doi: 10.3390/cells12121584. Cells. 2023. PMID: 37371054 Free PMC article. Review.
References
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources